本文選題：右美托咪啶 + 功能神經(jīng)外科麻醉　； 參考：《世界最新醫(yī)學(xué)信息文摘》2016年03期

【摘要】：目的探討右美托咪啶在功能神經(jīng)外科手術(shù)麻醉中的應(yīng)用效果。方法收集2014年4月至2015年4月神經(jīng)外科收治的住院部患者200例,隨機(jī)分為右美托咪啶組100例,對照組100例。兩組均與七氟烷、注射用苯磺順阿曲庫銨、枸櫞酸芬太尼注射液、丙泊酚麻醉,右美托咪啶組在此基礎(chǔ)上手術(shù)結(jié)束前30分鐘予右美托咪啶注射液0.4ug/kg配0.9%生理鹽水稀釋至20ml緩慢泵入,時間10分鐘;對照組僅予等量0.9%生理鹽水泵入,觀察兩組喚醒期血壓、心率、蘇醒時間、體動次數(shù)、嗆咳次數(shù)等。結(jié)果喚醒期右美托咪啶組收縮壓(118.8±10.3)mm Hg,對照組收縮壓(142.6±11.4)mm Hg;右美托咪啶組舒張壓(75.6±9.1)mm Hg,對照組舒張壓(90.8±12.2)mm Hg;右美托咪啶組心率(78.7±1.4)次/分,對照組心率(90.8±6.1)次/分。右美托咪啶組與對照組比較,差異均具有統(tǒng)計學(xué)意義(P0.05)。右美托咪啶組蘇醒時間為(5.33±2.58)分,對照組蘇醒時間(5.46±2.47)分,兩組比較差異無統(tǒng)計學(xué)意義(P0.05);右美托咪啶組體動次數(shù)為(0.05±0.23)次,對照組體動次數(shù)為(0.45±0.13)次,右美托咪啶組患者體動次數(shù)少于對照組;右美托咪啶組患者嗆咳次數(shù)為(1.2±0.3)次,對照組患者嗆咳次數(shù)為(3.5±1.3)次,兩組體動次數(shù)、嗆咳次數(shù)比較,差異具有統(tǒng)計學(xué)意義(P0.05)。結(jié)論右美托咪啶在功能神經(jīng)外科手術(shù)麻醉中無明顯抑制呼吸、循環(huán)系統(tǒng),并且可以減少手術(shù)應(yīng)激反應(yīng)。
[Abstract]:Objective to investigate the effect of dexmetidine in anaesthesia of functional neurosurgery. Methods from April 2014 to April 2015, 200 inpatient patients were randomly divided into dexmetomidine group (n = 100) and control group (n = 100). Both groups were anesthetized with sevoflurane, benzenesulfonate cisatracurium, fentanyl citrate injection, propofol, and propofol. On this basis, dexmetidine injection 0.4ug/kg and 0.9% normal saline were diluted to 20ml slowly for 10 minutes, while the control group was only given 0.9% saline to observe the blood pressure in the arousal phase, the control group was treated with dexmetidine injection 30 minutes before the end of operation, and the control group was injected with 0.9% saline for 10 minutes. Heart rate, recovery time, body movement, cough, etc. Results systolic blood pressure was 118.8 鹵10.3)mm Hg in dexmetidine group, 142.6 鹵11.4)mm Hg in control group, 75.6 鹵9.1)mm Hg in dexmetidine group, 90.8 鹵12.2)mm Hg in control group, 78.7 鹵1.4 beats / min in dexmetidine group and 90.8 鹵6.1 h / min in control group. The difference between dexmetidine group and control group was statistically significant (P 0.05). The recovery time of dexmetomidine group was 5.33 鹵2.58, and that of control group was 5.46 鹵2.47. There was no significant difference between the two groups (P 0.05 鹵0.23), while that of control group was 0.45 鹵0.13, while that of right metromidine group was 0.05 鹵0.23, while that of control group was 0.45 鹵0.13. The times of dysphagia were 1.2 鹵0.3 in dexmetidine group and 3.5 鹵1.3 in control group. The difference between the two groups was statistically significant (P 0.05). Conclusion dexmetidine has no significant inhibition on respiratory and circulatory system in functional neurosurgical anesthesia and can reduce the stress response.
【作者單位】： 遼寧省東港市中醫(yī)院;
【分類號】：R614

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