本文選題：枸杞多糖 + X射線　； 參考：《中成藥》2015年08期

【摘要】：目的觀察枸杞多糖對X射線電離輻射小鼠睪丸組織損傷的保護(hù)作用。方法雄性昆明小鼠隨機(jī)分為正常組、模型組、枸杞多糖低劑量和高劑量組,給藥組動物分別按照0.25 g/kg和1 g/kg劑量灌胃枸杞多糖,其余組動物灌胃蒸餾水,每日一次。第7天小鼠經(jīng)水合氯醛麻醉仰臥位固定,僅睪丸部位接受X射線照射(3.0 Gy),正常組小鼠僅麻醉不照射。照射后各組小鼠繼續(xù)灌胃藥物,第21天處死動物取睪丸及附睪,稱定質(zhì)量并觀察精子活力、精子密度以及睪丸生精小管結(jié)構(gòu)。結(jié)果枸杞多糖各組小鼠一般狀況均優(yōu)于模型組,枸杞多糖高劑量組小鼠睪丸質(zhì)量與模型組比較明顯增加,精子數(shù)量和活力明顯升高,組織病理學(xué)顯示枸杞多糖高劑量組小鼠睪丸生精小管內(nèi)含大量精子,部分區(qū)域見少量生精細(xì)胞脫落。結(jié)論枸杞多糖對X射線所致的小鼠睪丸組織損傷有明顯的保護(hù)作用。
[Abstract]:Objective to observe the protective effect of Lycium barbarum polysaccharides on testis injury induced by X-ray ionizing radiation in mice. Methods male Kunming mice were randomly divided into normal group, model group, low dose group and high dose group. The animals in the drug group were given intragastric administration of Lycium barbarum polysaccharides at the doses of 0.25 g/kg and 1 g/kg, respectively. The other groups were given distilled water once a day. On the 7th day, mice were anesthetized by chloral hydrate and fixed in supine position, and only the testis were exposed to 3.0 Gy of X-ray irradiation, while those in the normal group were only anesthetized and not irradiated. After irradiation, mice in each group continued to be gavaged. On the 21st day, the mice were killed to take testis and epididymis, and the sperm motility, sperm density and testicular seminiferous tubule structure were observed. Results the general status of Lycium barbarum polysaccharides in each group was better than that in the model group. The testis quality and sperm number and motility of the mice in the high dose group increased significantly compared with the model group. Histopathology showed that large amounts of spermatozoa were found in testis seminiferous tubules and a small number of spermatogenic cells were found in some regions in the high dose group of Lycium barbarum polysaccharides. Conclusion Lycium barbarum polysaccharide has obvious protective effect on X-ray induced testicular injury in mice.
【作者單位】： 浙江醫(yī)藥高等專科學(xué)校;寧波立華植物提取技術(shù)有限公司;
【基金】：高等學(xué)校訪問工程師校企合作項目(2012)
【分類號】：R285.5

【共引文獻(xiàn)】

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