本文選題：右美托咪定 + 后腹腔鏡手術(shù)�。� 參考：《臨床麻醉學(xué)雜志》2015年06期

【摘要】：目的探討右美托咪定在后腹腔鏡術(shù)中對應(yīng)激反應(yīng)的影響。方法擇期行后腹腔鏡下腎癌根治術(shù)的患者60例,男48例,女12例,年齡35~75歲,體重50~81kg,分為右美托咪定組(D組)和對照組(C組),每組30例。全身麻醉誘導(dǎo)前,D組10min內(nèi)靜脈泵入右美托咪定1μg/kg,續(xù)以0.5μg·kg-1·h-1泵入,手術(shù)結(jié)束前30min停藥。C組給予等量0.9%氯化鈉注射液。所有患者采用靜脈注射咪達(dá)唑侖0.02~0.04mg/kg、丙泊酚1.0~2.0mg/kg、順式阿曲庫銨0.2mg/kg及舒芬太尼0.5μg/kg進(jìn)行麻醉誘導(dǎo)。兩組患者術(shù)中連續(xù)監(jiān)測BP、HR、ECG、SpO2,記錄開始誘導(dǎo)泵入右美托咪定前(T0)、氣管插管即刻(T1)、開始?xì)飧箷r(T2)、拔出氣管導(dǎo)管后即刻(T3)和拔管5min后(T4)的MAP和HR,并于各時點抽取非靜脈輸液側(cè)肘靜脈血,放免法測定血漿皮質(zhì)醇(Cor)和血管緊張素-Ⅱ(A-Ⅱ)的水平。結(jié)果與C組比較,T0~T3時D組MAP明顯降低,HR明顯減慢(P0.05);與C組比較,T1~T3時D組的Cor濃度明顯降低(P0.05),T4時D組的A-Ⅱ濃度明顯降低(P0.05)。結(jié)論全麻中加入右美托咪定可以抑制圍術(shù)期應(yīng)激反應(yīng)。
[Abstract]:Objective to investigate the effect of dexmetidine on stress response during retroperitoneal laparoscopy. Methods A total of 60 patients (48 males and 12 females) who underwent retroperitoneal laparoscopic radical nephrectomy were divided into group D (group D) and control group (group C (n = 30), aged 35 ~ 75 years, weight 50 ~ 81kg). Before general anesthesia induction, dexmetomidine 1 渭 g / kg was injected intravenously into 10min in group D, followed by 0.5 渭 g kg-1 h-1. Before the end of operation, 0.9% sodium chloride was given to group C. All patients were induced by intravenous midazolam 0.02 mg / kg, propofol 1.0 mg / kg, cis atracurium 0.2mg/kg and sufentanil 0.5 渭 g/kg. Two groups of patients were monitored continuously during operation. The MAP and HRS of BPHRN ECG SpO2 were recorded. The MAP and HRS of BPHRN ECG SpO2 were recorded, and the non-venous infusion of elbow blood was taken at each time point. T1, T2, T3) and T4 after extubation were recorded immediately after endotracheal intubation and tracheal intubation, respectively. Plasma cortisol Corr and angiotensin 鈪，

本文編號：1853150