本文選題：中藥復方　切入點：鏈球菌性肺炎　出處：《中華中醫(yī)藥學刊》2017年04期

【摘要】：目的:觀察中藥復方對鏈球菌性肺炎小鼠炎癥p38MAPK信號轉導通路的影響。方法:將48只BALB/c小鼠隨機分為4組:正常組、模型組、中藥組、SB203580組,每組12只。模型組、中藥組、SB203580組采用麻醉并破損鼻黏膜滴注一定量肺炎鏈球菌法建立鏈球菌性肺炎模型;中藥組在造模后以中藥復方7.5 g·kg~(-1)·d~(-1)灌胃治療,2次·d~(-1),SB203580組造模后以SB203580 1mg·kg~(-1)·d~(-1)腹腔注射,1次·d~(-1),共7 d。造模第7天解剖取肺組織,檢測各組小鼠肺組織p38MAPK基因及p-p38MAPK蛋白表達水平和TNF-α、IL-6含量變化。結果:中藥組小鼠肺組織中p38MAPK基因及p-p38MAPK蛋白表達水平和TNF-α、IL-6含量較正常組高(P0.05),無統(tǒng)計學意義;較模型組低(P0.05),有統(tǒng)計學意義。結論:中藥復方能有效抑制鏈球菌性肺炎小鼠炎癥p38MAPK信號通路的活化,控制炎癥進程。
[Abstract]:Objective: to observe the effect of Chinese herbal prescription on inflammatory p38MAPK signal transduction pathway in streptococcal pneumonia mice. Methods: 48 BALB/c mice were randomly divided into 4 groups: normal group, model group, and traditional Chinese medicine group (SB203580, 12 rats in each group). The model of streptococcus pneumoniae was established in the traditional Chinese medicine group (SB203580) with anesthesia and nasal mucosal drip of a certain amount of streptococcus pneumoniae. The Chinese medicine group was treated by oral administration of traditional Chinese medicine (7.5g kg 路kg ~ (-1) 路d ~ (-1) d ~ (-1)) by intraperitoneal injection of SB203580 1mg / kg ~ (-1) D ~ (+ +) ~ (1) ~ (1) ~ (-1), and the lung tissue was dissected on the 7th day of model making, and the lung tissue was dissected on the 7th day of the model making, and the lung tissue was dissected and the lung tissue was dissected on the 7th day of the model. The expression level of p38MAPK gene and p-p38MAPK protein and the content of TNF- 偽 IL-6 in lung tissue of each group were detected. Results: the expression level of p38MAPK gene and p-p38MAPK protein and the content of TNF- 偽 -guan6 in the lung tissue of the Chinese medicine group were higher than those of the normal group (P 0.05), and there was no significant difference between the two groups. Conclusion: Chinese herbal prescription can effectively inhibit the activation of inflammatory p38MAPK signaling pathway and control the inflammatory process in mice with streptococcal pneumonia.
【作者單位】： 遼寧中醫(yī)藥大學教學實驗中心;
【基金】：遼寧省科技廳博士啟動基金項目(20131069)
【分類號】：R285.5

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本文編號：1672531