本文選題：中藥復(fù)方　切入點(diǎn)：鏈球菌性肺炎　出處：《中華中醫(yī)藥學(xué)刊》2017年04期

【摘要】：目的:觀察中藥復(fù)方對(duì)鏈球菌性肺炎小鼠炎癥p38MAPK信號(hào)轉(zhuǎn)導(dǎo)通路的影響。方法:將48只BALB/c小鼠隨機(jī)分為4組:正常組、模型組、中藥組、SB203580組,每組12只。模型組、中藥組、SB203580組采用麻醉并破損鼻黏膜滴注一定量肺炎鏈球菌法建立鏈球菌性肺炎模型;中藥組在造模后以中藥復(fù)方7.5 g·kg~(-1)·d~(-1)灌胃治療,2次·d~(-1),SB203580組造模后以SB203580 1mg·kg~(-1)·d~(-1)腹腔注射,1次·d~(-1),共7 d。造模第7天解剖取肺組織,檢測(cè)各組小鼠肺組織p38MAPK基因及p-p38MAPK蛋白表達(dá)水平和TNF-α、IL-6含量變化。結(jié)果:中藥組小鼠肺組織中p38MAPK基因及p-p38MAPK蛋白表達(dá)水平和TNF-α、IL-6含量較正常組高(P0.05),無(wú)統(tǒng)計(jì)學(xué)意義;較模型組低(P0.05),有統(tǒng)計(jì)學(xué)意義。結(jié)論:中藥復(fù)方能有效抑制鏈球菌性肺炎小鼠炎癥p38MAPK信號(hào)通路的活化,控制炎癥進(jìn)程。
[Abstract]:Objective: to observe the effect of Chinese herbal prescription on inflammatory p38MAPK signal transduction pathway in streptococcal pneumonia mice. Methods: 48 BALB/c mice were randomly divided into 4 groups: normal group, model group, and traditional Chinese medicine group (SB203580, 12 rats in each group). The model of streptococcus pneumoniae was established in the traditional Chinese medicine group (SB203580) with anesthesia and nasal mucosal drip of a certain amount of streptococcus pneumoniae. The Chinese medicine group was treated by oral administration of traditional Chinese medicine (7.5g kg 路kg ~ (-1) 路d ~ (-1) d ~ (-1)) by intraperitoneal injection of SB203580 1mg / kg ~ (-1) D ~ (+ +) ~ (1) ~ (1) ~ (-1), and the lung tissue was dissected on the 7th day of model making, and the lung tissue was dissected on the 7th day of the model making, and the lung tissue was dissected and the lung tissue was dissected on the 7th day of the model. The expression level of p38MAPK gene and p-p38MAPK protein and the content of TNF- 偽 IL-6 in lung tissue of each group were detected. Results: the expression level of p38MAPK gene and p-p38MAPK protein and the content of TNF- 偽 -guan6 in the lung tissue of the Chinese medicine group were higher than those of the normal group (P 0.05), and there was no significant difference between the two groups. Conclusion: Chinese herbal prescription can effectively inhibit the activation of inflammatory p38MAPK signaling pathway and control the inflammatory process in mice with streptococcal pneumonia.
【作者單位】： 遼寧中醫(yī)藥大學(xué)教學(xué)實(shí)驗(yàn)中心;
【基金】：遼寧省科技廳博士啟動(dòng)基金項(xiàng)目(20131069)
【分類號(hào)】：R285.5

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1 周志男;孫美平;;兒童鏈球菌性肺炎流行病學(xué)研究[J];世界臨床藥物;2011年12期

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本文編號(hào)：1672531