本文選題：鹽酸右美托咪定　切入點(diǎn)：異丙酚　出處：《中國(guó)藥房》2016年03期 　論文類型：期刊論文

【摘要】：目的:比較鹽酸右美托咪定與異丙酚在無痛結(jié)腸鏡檢查中的麻醉效果和安全性。方法:80例擬行無痛結(jié)腸鏡檢查患者隨機(jī)均分為A組和B組。A組患者30 s內(nèi)泵注異丙酚負(fù)荷劑量1 mg/kg,后以6 mg/(kg·h)維持;B組患者5 min內(nèi)微量泵緩慢泵注鹽酸右美托咪定注射液負(fù)荷劑量0.3μg/kg,后以0.2~0.3μg/(kg·h)維持。觀察兩組患者檢查前(T_0),給藥后鏡檢開始前(T_1),鏡檢開始后1 min(T_2)、10 min(T_3),退鏡完畢后1 min(T_4)、5 min(T_5)的平均動(dòng)脈壓(MAP)、心率(HR)、血氧飽和度(SPO_2)及呼吸頻率(RR),麻醉起效時(shí)間、入鏡時(shí)間、檢查時(shí)間、離院時(shí)間,輔助使用芬太尼患者例數(shù)及不良反應(yīng)發(fā)生情況。結(jié)果:A組患者T_1時(shí)的MAP顯著低于同組T_0時(shí),兩組患者T_1~T_3時(shí)的HR均顯著低于同組T_0時(shí),差異均有統(tǒng)計(jì)學(xué)意義(P0.05),但兩組患者各時(shí)點(diǎn)的SpO_2、RR比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。B組患者麻醉起效時(shí)間、輔助使用芬太尼患者例數(shù)、不良反應(yīng)發(fā)生率均顯著低于A組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:鹽酸右美托咪定與異丙酚在無痛結(jié)腸鏡檢查中均有較好的麻醉效果,但鹽酸右美托咪定安全性更好。
[Abstract]:Objective: to compare the anesthetic effect and safety of dexmetidine hydrochloride and propofol in painless colonoscopy. Methods: 80 patients with painless colonoscopy were randomly divided into group A and group B. The loading dose of propofol was 1 mg / kg, then 6 mg/(kg 路h). The loading dose of dexmetomidine hydrochloride injection was 0.3 渭 g / kg for 5 min and 0.2 渭 g / kg 路h for dexmetidine hydrochloride injection respectively. The mean arterial pressure (MAPP), heart rate (HRT), blood oxygen saturation (SPO _ 2) and respiratory frequency (RRN), the onset time of anesthesia, were observed at 1 min after the beginning and 1 min after the end of the endoscopy. Results the MAP of group 1 was significantly lower than that of T _ 0 in group A, and the HR at T _ 1T _ 3 in both groups was significantly lower than that of T _ 0 in group T _ (1) and T _ (1) T _ (3) in both groups, the number of patients with Fentanyl plus fentanyl and the incidence of adverse reactions were significantly lower than those in group T _ (1) and T _ (0). The difference was statistically significant (P 0.05), but there was no significant difference between the two groups in SpO2RR at different time points. There was no significant difference in the onset time of anesthesia, the number of patients with auxiliary use of fentanyl, and the incidence of adverse reactions were significantly lower in group B than in group A. Conclusion: dexmetidine hydrochloride and propofol have better anaesthesia effect in painless colonoscopy, but dexmetomidine hydrochloride is more safe.
【作者單位】： 天津中醫(yī)藥大學(xué)第一附屬醫(yī)院;天津醫(yī)科大學(xué)腫瘤醫(yī)院麻醉科;
【分類號(hào)】：R614

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