本文選題：吸入性麻醉　切入點(diǎn)：氣道炎癥反應(yīng)　出處：《中國醫(yī)療器械信息》2016年10期 　論文類型：期刊論文

【摘要】：目的:探索不同麻醉機(jī)消毒方法對手術(shù)合并COPD吸入性麻醉患者氣道炎癥反應(yīng)的影響。方法:有慢性阻塞性肺病(COPD)患者70例,隨機(jī)均分為兩組(n=35),觀察組患者采用術(shù)前經(jīng)環(huán)氧乙烷浸泡消毒的麻醉機(jī)進(jìn)行麻醉;對照組患者則術(shù)前采用2%戊二醛溶液浸泡消毒麻醉機(jī)進(jìn)行麻醉。檢測兩組插管后及插管后2h、4h血清及肺泡灌洗液中的TNF-α水平、IL-8、IL-2及IL-1β的濃度。結(jié)果:兩組各血清因子濃度隨時間延長而增加,插管后2h、4h各個指標(biāo)濃度較剛插管后均顯著增加(P均0.05)。兩組肺泡灌洗液中各指標(biāo)濃度隨時間延長而增加,插管后2h、4h各個指標(biāo)濃度較剛插管后均顯著增加(P0.05)。IL-2濃度在各個時段觀察組的濃度均顯著低于對照組(P0.05)。TNF-α水平在插管后2h、4h時觀察組濃度明顯低于對照組,IL-8插管后2h時觀察組濃度明顯低于對照組,差異均有統(tǒng)計學(xué)意義(P0.05)。結(jié)論:COPD吸入性麻醉患者使用環(huán)氧乙烷消毒的麻醉機(jī)對氣道炎癥反應(yīng)影響較小,環(huán)氧乙烷的消毒效果優(yōu)于2%戊二醛溶液,對氣道有一定的保護(hù)作用。
[Abstract]:Objective: to explore the effect of different anesthetic machine disinfection methods on airway inflammation in patients with COPD inhalation anesthesia. Methods: 70 patients with chronic obstructive pulmonary disease (COPD) were enrolled in this study. All the patients were randomly divided into two groups. The patients in the observation group were anesthetized with anaesthesia machine which was soaked and disinfected by ethylene oxide before operation. The patients in the control group were anesthetized with 2% glutaraldehyde solution immersion disinfectant anaesthesia machine before operation. The levels of TNF- 偽 and IL-8 IL-2 and IL-1 尾 in serum and alveolar lavage fluid were measured after intubation and 2 h after intubation. Results: each serum factor in both groups was determined. The concentration increases with time, Two hours after intubation, the concentration of each index was significantly higher than that after intubation (P < 0.05). The concentration of each index in alveolar lavage fluid of two groups increased with the prolongation of time. Two hours after intubation, the concentration of each index was significantly higher than that after intubation. The concentration of IL-2 in observation group was significantly lower than that in control group 2 hours after intubation. The concentration of TNF- 偽 in observation group was significantly lower than that in control group at 2 h after intubation and 2 h after intubation. The concentration of IL-2 in observation group was significantly lower than that in control group at 2 h after intubation. The concentration of observation group was significantly lower than that of control group. Conclusion the anesthetic machine disinfected by ethylene oxide has little effect on airway inflammation, and the disinfection effect of ethylene oxide is better than that of 2% glutaraldehyde solution, and it has a certain protective effect on airway.
【作者單位】： 遼陽市第二人民醫(yī)院麻醉科;
【分類號】：R614

【參考文獻(xiàn)】

相關(guān)期刊論文 前5條

1 王小玲;劉侃;;環(huán)氧乙烷消毒麻醉機(jī)對COPD吸入麻醉患者氣道炎癥反應(yīng)的影響[J];河北醫(yī)學(xué);2015年10期

2 周學(xué)穎;趙峰;王萃;王瑩瑩;周樂;;兩種麻醉機(jī)消毒方法效果比較[J];中華醫(yī)院感染學(xué)雜志;2015年15期

3 張瑋;萬福紅;梁寧;;不同干預(yù)方法對麻醉機(jī)通氣系統(tǒng)病原微生物的影響[J];廣西醫(yī)學(xué);2014年12期

4 呂紅杰;董麗娟;吳亞輝;;麻醉機(jī)通氣系統(tǒng)污染與全麻術(shù)后肺部感染的臨床分析[J];中華醫(yī)院感染學(xué)雜志;2014年18期

5 郭凱;黃美玲;崔紹敏;;麻醉機(jī)通氣系統(tǒng)污染與患者全麻術(shù)后肺部感染的相關(guān)性研究[J];中華醫(yī)院感染學(xué)雜志;2014年17期

【共引文獻(xiàn)】

相關(guān)期刊論文 前6條

1 劉U，

本文編號：1610980