本文選題：纖維結(jié)腸鏡　切入點(diǎn)：無(wú)痛　出處：《中國(guó)臨床藥理學(xué)雜志》2015年10期 　論文類型：期刊論文

【摘要】：目的評(píng)價(jià)右美托咪定復(fù)合丙泊酚用于無(wú)痛纖維結(jié)腸鏡檢查術(shù)的臨床療效及安全性。方法將48例擬進(jìn)行纖維結(jié)腸鏡檢查的患者隨機(jī)分為試驗(yàn)組22例和對(duì)照組26例。對(duì)照組靜脈注射丙泊酚2.5 mg·kg-1,術(shù)中根據(jù)患者麻醉情況追加0.5~1.0 mg·kg-1。試驗(yàn)組首先緩慢靜脈推注(10 min)右美托咪定1μg·kg-1,然后靜脈注射丙泊酚2 mg·kg-1。2組患者麻醉后置入纖維結(jié)腸鏡,并尋腔進(jìn)鏡對(duì)患者腸腔內(nèi)壁進(jìn)行檢查。檢查過程中分析比較2組患者的鎮(zhèn)痛效果、起效時(shí)間、蘇醒時(shí)間、離院時(shí)間及麻醉過程中的不良反應(yīng)發(fā)生率有無(wú)差別。結(jié)果試驗(yàn)組鎮(zhèn)痛效果明顯優(yōu)于對(duì)照組(P0.05)。試驗(yàn)組起效時(shí)間、蘇醒時(shí)間及離院時(shí)間均明顯短于對(duì)照組,丙泊酚用量小于對(duì)照組(均P0.05)。試驗(yàn)組頭暈及躁動(dòng)發(fā)生率顯著低于對(duì)照組(均P0.05),而惡心嘔吐、舌后墜及呼吸抑制發(fā)生率比較差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論右美托咪定復(fù)合丙泊酚用于無(wú)痛纖維結(jié)腸鏡檢查鎮(zhèn)痛效果好,不良反應(yīng)發(fā)生率低。
[Abstract]:Objective to evaluate the clinical efficacy and safety of dexmetomidine combined with propofol in painless fibercolonoscopy. Methods 48 patients were randomly divided into trial group (n = 22) and control group (n = 26). In the control group, propofol 2.5 mg 路kg -1 was injected intravenously, and 0.5 mg 路kg -1 was added during the operation according to the anesthetic condition of the patients. In the trial group, 1 渭 g 路kg -1 dexmetomidine was injected slowly for 10 minutes. Then the patients in the 2 mg 路kg-1.2 group received intravenous injection of propofol were treated with fibrocolonoscopy after anesthesia. During the examination, the analgesic effect, the effective time and the recovery time of the two groups were analyzed and compared. Results the analgesic effect of the experimental group was significantly better than that of the control group (P 0.05). The onset time, recovery time and absence time of the experimental group were significantly shorter than that of the control group. The dosage of propofol was lower than that of the control group (all P 0.05). The incidence of dizziness and restlessness in the trial group was significantly lower than that in the control group (all P 0.05), but nausea and vomiting. There was no significant difference in the incidence of retrolingual locus and respiratory depression. Conclusion dexmetomidine combined with propofol has good analgesic effect and low incidence of adverse reactions in painless fibercolonoscopy.
【作者單位】： 衢州市人民醫(yī)院普外科;
【基金】：浙江衢州市科技基金資助項(xiàng)目(2014P022)
【分類號(hào)】：R614

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