本文選題：超前鎮(zhèn)痛　切入點(diǎn)：普瑞巴林　出處：《中國(guó)臨床藥理學(xué)雜志》2017年17期 　論文類型：期刊論文

【摘要】：目的觀察骨科腰椎手術(shù)患者用不同劑量的普瑞巴林預(yù)先給藥聯(lián)合自控鎮(zhèn)痛(PCA)對(duì)術(shù)后早期疼痛的影響。方法擇期進(jìn)行腰椎管狹窄癥腰椎椎板減壓手術(shù)的患者54例,隨機(jī)分為高、中、低劑量組,每組18例。分別于麻醉前2 h口服普瑞巴林300,150,75 mg,術(shù)后脫機(jī)即開始自控鎮(zhèn)痛,記錄術(shù)后2,6,12,24 h患者的視覺模擬評(píng)分(VAS)及術(shù)后24 h內(nèi)自控鎮(zhèn)痛藥物用量及藥物不良反應(yīng)發(fā)生率。結(jié)果術(shù)后2 h,高、中、低劑量組VAS評(píng)分分別為3.72±1.27,3.67±1.14,4.78±1.31,高、中劑量組與低劑量組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。術(shù)后6 h,高、中、低劑量組VAS評(píng)分分別為3.06±0.80,3.28±1.49,4.00±0.69,高劑量組與低劑量組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。術(shù)后12 h,高、中、低劑量組VAS評(píng)分分別為2.28±0.67,3.11±1.28,3.33±0.84,高、中劑量組與低劑量組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。術(shù)后24 h,高、中、低劑量組VAS評(píng)分分別為2.17±0.62,2.83±1.10,2.83±0.71,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。高劑量組出現(xiàn)頭暈伴惡心嘔吐1例,嗜睡1例,惡心嘔吐1例,藥物不良反應(yīng)發(fā)生率為16.67%(3/18例);中、低劑量組分別出現(xiàn)惡心嘔吐1例,藥物不良反應(yīng)均為5.56%(1/18例),3組藥物不良反應(yīng)發(fā)生率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論普瑞巴林預(yù)先給藥用于骨科手術(shù),術(shù)后早期鎮(zhèn)痛效果良好,并且藥物不良反應(yīng)發(fā)生率低,300 mg的預(yù)先給藥可能是一個(gè)較好的方案。
[Abstract]:Objective To observe the patients of Department of orthopedics lumbar surgery with different dose of pregabalin administered with patient-controlled analgesia in advance (PCA) effect on early postoperative pain. Methods 54 patients undergoing lumbar spinal stenosis lumbar decompression surgery, were randomly divided into high, low dose group, each group of 18 cases respectively before anesthesia, 2. H 300150,75 mg oral pregabalin, postoperative analgesia is offline, 2,6,12,24 h of postoperative patients with visual analogue scale (VAS) and postoperative adverse reactions within 24 h analgesic drugs and incidence. Results after 2 h, high, low dose group, VAS score was 3.72 + 1.27,3.67 + 1.14,4.78 + 1.31, high, middle dose group and low dose group, the difference was statistically significant (P0.05). After 6 h, high, low dose group, VAS score was 3.06 + 0.80,3.28 + 1.49,4.00 + 0.69, high dose group and low dose group, the difference was statistically Statistically significant (P0.05). After 12 h, high, low dose group, VAS score was 2.28 + 0.67,3.11 + 1.28,3.33 + 0.84, high, middle dose group and low dose group, the difference was statistically significant (P0.05). After 24 h, high, low dose group, VAS score were 2.17 + 0.62,2.83 + 1.10,2.83 + 0.71, the difference was not statistically significant (P0.05). Dizziness nausea and vomiting in 1 cases with high dose group, 1 cases in 1 cases of drowsiness, nausea and vomiting, the incidence of adverse reaction was 16.67% (3/18 cases), low dose group; there were 1 cases of nausea and vomiting, no drugs adverse reactions were 5.56% (1/18 cases), drug adverse reactions of the 3 groups there was no significant difference between them (P0.05). Conclusion pregabalin pretreatment for Department of orthopedics operation, postoperative analgesia effect is good, and the incidence of adverse drug reactions, 300 mg pretreatment may be a better solution.

【作者單位】： 吉化集團(tuán)公司總醫(yī)院骨科;吉化集團(tuán)公司總醫(yī)院麻醉科;
【分類號(hào)】：R614

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