本文關(guān)鍵詞：麻醉方式對老年膝關(guān)節(jié)置換術(shù)患者術(shù)后認(rèn)知功能影響　出處：《浙江創(chuàng)傷外科》2016年02期 　論文類型：期刊論文

  更多相關(guān)文章： 麻醉方式 老年膝關(guān)節(jié)置換患者 認(rèn)知功能 認(rèn)知功能障礙

【摘要】：目的觀察麻醉方式對老年膝關(guān)節(jié)置換術(shù)患者術(shù)后認(rèn)識功能的影響,為臨床麻醉提供參考。方法選取本院收治老年膝關(guān)節(jié)置換術(shù)患者150例為研究對象,隨機(jī)分為觀察組和對照組,對照組全麻,觀察組腰硬聯(lián)合麻醉。觀察患者認(rèn)知功能變化,并比較患者各指標(biāo)變化。結(jié)果術(shù)后1天和術(shù)后5天,觀察組患者M(jìn)MSE評分均顯著高于對照組,P0.05。術(shù)后1天,觀察組患者PDCD發(fā)生率顯著低于對照組,P0.05;術(shù)后5天,觀察組患者PDCD發(fā)生率低于對照組,但差異不明顯,P0.05。觀察組和對照組T1時刻和T3時刻Tau蛋白血清濃度無明顯差異,P0.05;T2時刻,觀察組Tau蛋白血清濃度顯著低于對照組,P0.05。POCD組和非POCD組T1時刻和T3時刻Tau蛋白無明顯差異,P0.05;T2時刻,POCD組Tau蛋白血清濃度顯著高于非POCD組,P0.05。結(jié)論老年膝關(guān)節(jié)置換術(shù)患者治療中,采用腰硬聯(lián)合麻醉方式能夠提高認(rèn)知功能,減少POCD發(fā)生率,Tau蛋白濃度升高可能會引起POCD的發(fā)生。
[Abstract]:Objective to observe the effect of anaesthesia on the cognitive function of elderly patients undergoing knee arthroplasty, and to provide reference for clinical anesthesia. Methods 150 cases of senile knee arthroplasty in our hospital were selected as the research objects. They were randomly divided into observation group and control group, general anesthesia in control group, combined spinal-epidural anesthesia in observation group. The changes of cognitive function were observed, and the indexes of patients were compared. Results 1 day after operation and 5 days after operation. The MMSE scores in the observation group were significantly higher than those in the control group (P 0.05). The incidence of PDCD in the observation group was significantly lower than that in the control group 1 day after operation (P 0.05). 5 days after operation, the incidence of PDCD in the observation group was lower than that in the control group, but the difference was not significant (P 0.05). There was no significant difference in the serum concentration of Tau protein between the observation group and the control group at T1 and T3. P0.05; At T2 time, the serum concentration of Tau protein in the observation group was significantly lower than that in the control group P0.05.POCD group and non-#en1# group. There was no significant difference in Tau protein between the control group and non-#en1# group at T1 and T3 time. The serum concentration of Tau protein was significantly higher in POCD group than that in non-#en1# group at T2 moment (P 0.05). Conclusion in the elderly patients with knee arthroplasty, the serum concentration of Tau protein is significantly higher than that in the control group. Combined spinal-epidural anesthesia can improve cognitive function and reduce the incidence of POCD. The increase of Tau protein concentration may lead to the occurrence of POCD.
【作者單位】： 溫州醫(yī)科大學(xué)附屬第三醫(yī)院;溫州醫(yī)科大學(xué)附屬第一醫(yī)院;
【分類號】：R614
【正文快照】： 術(shù)后認(rèn)知功能障是指術(shù)前無精神異常而術(shù)后出現(xiàn)大腦功能紊亂的情況,包括認(rèn)知、定量、精神等方面的異常。很多研究[1,2]發(fā)現(xiàn)老年膝關(guān)節(jié)置換術(shù)術(shù)后患者認(rèn)知功能障礙(POCD)發(fā)病率很高,存在多種影響因素。有研究發(fā)現(xiàn),不同麻醉方式對POCD的影響不同,其中全麻患者術(shù)后認(rèn)知功能障礙發(fā)

【參考文獻(xiàn)】

相關(guān)期刊論文 前9條

1 李海英;;腹腔鏡膽囊切除術(shù)患者應(yīng)用不同全身麻醉方式麻醉的效果及患者認(rèn)知功能變化[J];實用臨床醫(yī)藥雜志;2015年17期

2 趙助宏;易能芬;;全麻復(fù)合硬膜外麻醉對老年腹部手術(shù)患者肺功能和術(shù)后認(rèn)知功能的影響[J];浙江創(chuàng)傷外科;2015年04期

3 呂治力;;老年創(chuàng)傷患者采用不同麻醉方式對術(shù)后早期認(rèn)知功能的影響分析[J];中國療養(yǎng)醫(yī)學(xué);2015年06期

4 何燕娜;張縣強;;全身麻醉和單側(cè)腰-硬聯(lián)合麻醉對老年創(chuàng)傷患者認(rèn)知功能恢復(fù)的比較分析[J];浙江創(chuàng)傷外科;2015年03期

5 張百軍;楊趙棟;鄭e，

本文編號：1439680