本文關(guān)鍵詞：腹式子宮切除術(shù)中0.6%甲磺酸羅哌卡因脊髓麻醉的有效劑量　出處：《中國現(xiàn)代醫(yī)學雜志》2016年03期 　論文類型：期刊論文

  更多相關(guān)文章： .%甲磺酸羅哌卡因 蛛網(wǎng)膜下腔阻滯 有效劑量 腹式子宮切除術(shù)

【摘要】：目的觀察研究0.6%甲磺酸羅哌卡因在腹式子宮切除術(shù)腰麻聯(lián)合硬膜外麻醉中蛛網(wǎng)膜下腔阻滯的有效劑量。方法隨機選取婦科腹式子宮切除術(shù)患者80例,按隨機數(shù)字表法分為4組,每組20例。單因素設計,采用序貫試驗的Robbins-Monro法,監(jiān)測血壓、心電圖、術(shù)中惡心、嘔吐,觀察感覺神經(jīng)和運動神經(jīng)阻滯、術(shù)后并發(fā)癥及追蹤1個月后肝、腎功能是否發(fā)生變化,記錄達到有效劑量標準、超過有效劑量標準、未達到有效劑量標準的情況,并據(jù)此分析研究。結(jié)果在腹式子宮切除術(shù)腰麻聯(lián)合硬膜外麻醉中,應用0.6%甲磺酸羅哌卡因使蛛網(wǎng)膜下腔阻滯達到有效標準者的生命體征平穩(wěn),心電圖未見明顯變化,術(shù)中偶有惡心,無嘔吐。其半數(shù)有效劑量(ED50)為15.33 mg,95%可信區(qū)間為13.56,16.76。結(jié)論 0.6%甲磺酸羅哌卡因可以安全有效地應用于腰麻聯(lián)合硬膜外麻醉蛛網(wǎng)膜下腔阻滯,ED50為15.33 mg,無明顯毒副作用,對循環(huán)影響較輕。
[Abstract]:Objective To observe and study the effective dose of 0.6% mesylate ropivacaine for subarachnoid block during abdominal anesthesia combined with epidural anesthesia for abdominal hysterectomy. Methods 80 cases of gynecologic abdominal hysterectomy were randomly selected and divided into 4 groups according to the random digital table method, with 20 cases in each group. The single factor design, Robbins-Monro method using sequential test, blood pressure, electrocardiogram, intraoperative nausea and vomiting, observation of the sensory nerve and motor nerve block, postoperative complications and follow-up 1 months after liver and kidney function is changed, the effective dose to record standard, more effective than did not reach the standard, the standard dose and effective dose and based on the analysis and research. Results in abdominal spinal hysterectomy, spinal epidural anesthesia, 0.6% methanesulfonic acid ropivacaine for subarachnoid block to achieve effective standards of vital signs were stable, ECG did not change significantly, intraoperative occasionally nausea and vomiting. The median effective dose (ED50) was 15.33 mg and the 95% confidence interval was 13.56,16.76. Conclusion 0.6% methanesulfonic acid ropivacaine can be safely and effectively applied to spinal anesthesia combined with epidural anesthesia for subarachnoid block, ED50 is 15.33 mg, has no obvious side effects, and has less effect on circulation.
【作者單位】： 內(nèi)蒙古科技大學包頭醫(yī)學院第一附屬醫(yī)院麻醉科;
【基金】：內(nèi)蒙古自治區(qū)衛(wèi)生和計劃生育委員會資助項目(No:201302105)
【分類號】：R614.41
【正文快照】： 甲磺酸羅哌卡因是一新型酰胺類局部麻醉藥,穩(wěn)定性好,藥代動力學與鹽酸羅哌卡因相似[1],神經(jīng)毒性較弱,已廣泛應用于臨床麻醉,推測其在蛛網(wǎng)膜下腔阻滯中可能對循環(huán)影響較小。國外文獻未見甲磺酸羅哌卡因用于蛛網(wǎng)膜下腔的有關(guān)報道。汪俊芳等[2]報道大鼠蛛網(wǎng)膜下腔注射甲磺酸羅哌

【參考文獻】

相關(guān)期刊論文 前1條

1 程良道;張冰;宋R，

本文編號：1338557