【摘要】：目的探討新建立的澳門健康成人脈沖振蕩肺功能各主要指標預計值方程式在老年COPD患者中的診斷價值。方法對97例老年COPD患者及47例健康老年人應用脈沖振蕩肺功能測定氣道阻力,與常規(guī)肺通氣功能、新建立的澳門健康成人脈沖振蕩肺功能各主要指標預計值和廠家預計值進行比較,對比分析它們對COPD的診斷價值。結果 COPD男女兩組Zrs、R5、(R5-R20)、RF均高于健康對照組,男性COPD組R20亦高于健康對照組;X5、X20 COPD組均低于健康對照組。除女性組R5 A/P1(廠家預計值)與FEV1/FVC%、FEV1/Pre%相關性稍高外,余男女兩組Zrs、R20、X5等指標均為P2(新建立的澳門健康成人脈沖振蕩肺功能各主要指標預計值)與FEV1/FVC%、FEV1/Pre%相關性最高。RF、Zrs、(R5-R20)、R5、R20、X5(P2-A)等指標均與FEV1/FVC%、FEV1/Pre%呈顯著負相關,其中RF的相關性最為密切,其余依次為女性組:Zrs(A/P2)、(R5-R20)、X5(P2-A)、R5、R20;男性組,與FEV1/FVC%相關的順序為Zrs(A/P2)、X5(P2-A)、(R5-R20)、R5、R20。與FEV1/Pre%相關的順序為X5(P2-A)、Zrs(A/P2)、(R5-R20)、R5、R20。IOS各指標ROC曲線下面積分析顯示,Zrs(A/P2)、R5(A/P2)、R20(A/P2)、R20(A/P2)、X5(P2-A)分別大于Zrs(A/P1)及Zrs(A)、R5(A/P1)、R20(A/P1)、R20(A/P1)、X5(P1-A)。男性組Zrs(A/P2)%≥113.7時,R5(A/P2)%≥133.4時,R20(A/P2)%≥77.4時,X5(P2-A)≥0.035時,RF≥15.9時,各約登指數最高。女性組Zrs(A/P2)%≥127.7時,R5(A/P2)%≥121.7時,R20(A/P2)%≥129.5時,X5(P2-A)≥0.005時,RF≥18時,各約登指數最高。結論脈沖振蕩肺功能對COPD具有診斷價值,根據澳門本地人群建立的正常預計值方程式在診斷COPD時,其敏感性、特異性均高于廠家預計值,建議推廣應用。
[Abstract]:Objective to investigate the diagnostic value of the predicted values of pulse oscillatory pulmonary function in elderly patients with COPD. Methods Airway resistance was measured by pulse oscillatory pulmonary function in 97 elderly patients with COPD and 47 healthy elderly. The predicted values of main indexes and manufacturers of pulse oscillatory pulmonary function in healthy adults in Macao were compared with those of conventional pulmonary ventilation, and their diagnostic value for COPD was compared and analyzed. Results Zrs,R5, (R5-R20), RF) in both male and female groups of COPD was higher than that in healthy control group, R20 in male COPD group was also higher than that in healthy control group, and X5, X20 COPD group was lower than that in healthy control group. Except that the correlation between R5 A/P1 and FEV1/FVC%,FEV1/Pre% was slightly higher in the female group, the indexes such as Zrs,R20,X5 were P2 (the predicted values of the main indexes of pulse oscillatory lung function in healthy adults in Macao) were the highest correlation with FEV1/FVC%,FEV1/Pre%. RF, Zrs, (R5-R20), R5, R20, X5 (P 2 鈮，

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