【摘要】：目的探討老年慢性阻塞性肺疾病急性加重期(AECOPD)患者血清C反應(yīng)蛋白(CRP)、降鈣素原(PCT)的水平變化及其意義。方法選取沙坪壩區(qū)人民醫(yī)院呼吸內(nèi)科2013年1月至2015年6月收治的120例老年AECOPD患者進(jìn)行研究,根據(jù)BODE指數(shù)(體質(zhì)量、呼吸困難、氣流、運(yùn)動(dòng)功能指數(shù))、治療后1年內(nèi)出現(xiàn)急性加重次數(shù)、復(fù)發(fā)時(shí)間進(jìn)行亞組分析,另選擇40例門(mén)診健康體檢者作為對(duì)照組,對(duì)比各組血清CRP、PCT水平。結(jié)果 BODE指數(shù)1~4級(jí)的AECOPD患者血清CRP、PCT水平均顯著高于對(duì)照組(P0.05),且組內(nèi)血清CRP、PCT水平比較:1級(jí)2級(jí)3級(jí)4級(jí),差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。AECOPD患者血清CRP、PCT水平與BODE指數(shù)分級(jí)之間呈正相關(guān)(r=0.482、0.317,P0.05)。治療后,超過(guò)3個(gè)月出現(xiàn)復(fù)發(fā)的AECOPD患者血清CRP、PCT水平顯著低于3個(gè)月內(nèi)復(fù)發(fā)的患者,差異均有統(tǒng)計(jì)學(xué)意義(P0.05);治療出院后1年,復(fù)發(fā)次數(shù)超過(guò)1次的AECOPD患者血清CRP、PCT水平顯著高于復(fù)發(fā)少于或等于1次的患者,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 AECOPD患者的血清CRP、PCT水平可以反映患者的呼吸困難、氣流受限、運(yùn)動(dòng)功能,并且能對(duì)患者預(yù)后進(jìn)行初步評(píng)估。
[Abstract]:Objective to investigate the changes and significance of serum C-reactive protein (CRP), procalcitonin (PCT) in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods from January 2013 to June 2015, 120 elderly patients with AECOPD admitted to the Department of Respiratory Medicine of Shapingba District people's Hospital were studied according to BODE index (body mass, dyspnea, airflow, motor function index). One year after treatment, the times of acute aggravation and recurrence time were analyzed by subgroup analysis, and 40 outpatients were selected as control group to compare the level of serum CRP,PCT in each group. Results the serum CRP,PCT level of AECOPD patients with BODE index 1 鈮，

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