脂聯(lián)素在支氣管哮喘中的作用
發(fā)布時(shí)間:2019-05-23 00:52
【摘要】:目的評(píng)估血清及誘導(dǎo)痰脂聯(lián)素與哮喘炎癥狀態(tài)的關(guān)系。方法 42例哮喘患者按ACT評(píng)分分為控制不良組(ACT25分,n=24)、完全控制組(ACT=25分,n=18),10例健康人作對(duì)照組,檢測其血清及誘導(dǎo)痰上清液中脂聯(lián)素、白細(xì)胞介素-13(IL-13)的濃度、血清C反應(yīng)蛋白(CRP)濃度并測量身高、體質(zhì)量,計(jì)算體質(zhì)量指數(shù)(BMI)。結(jié)果控制不良組血清及誘導(dǎo)痰脂聯(lián)素、IL-13濃度、血清CRP濃度均高于完全控制組及對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.01),完全控制組誘導(dǎo)痰脂聯(lián)素及血清IL-13濃度高于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。哮喘患者血清脂聯(lián)素與血清CRP、血清IL-13正相關(guān)(r=0.51,P0.01;r=0.84,P0.01),誘導(dǎo)痰脂聯(lián)素與血清CRP負(fù)相關(guān)(r=-0.52,P0.01)。結(jié)論在哮喘中脂聯(lián)素與CRP、IL-13相關(guān),其參與了哮喘的氣道及全身炎癥反應(yīng),是一種新的哮喘炎癥標(biāo)志物。
[Abstract]:Objective to evaluate the relationship between serum and induced sputum adiponectin and inflammatory state of asthma. Methods 42 patients with asthma were divided into poor control group (ACT25 score, n 鈮,
本文編號(hào):2483447
[Abstract]:Objective to evaluate the relationship between serum and induced sputum adiponectin and inflammatory state of asthma. Methods 42 patients with asthma were divided into poor control group (ACT25 score, n 鈮,
本文編號(hào):2483447
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