【摘要】：目的：回顧性分析呼吸道常見病原體感染與慢性阻塞性肺疾病急性加重期（AECOPD）的關(guān)系及對血?dú)夥治龅挠绊�。方法：�?011年2月至2013年2月我院呼吸科收住的200例AECOPD患者的血清標(biāo)本應(yīng)用呼吸道聯(lián)檢試劑(間接免疫熒光法)同時(shí)檢測9項(xiàng)主要病原體的IgM抗體，包括甲型流感病毒(IFA)、乙型流感病毒(IFB)、嗜肺軍團(tuán)菌(LP)、肺炎衣原體(CP)、肺炎支原體(MP)、呼吸道合胞病毒(RSV)、腺病毒(ADV)、副流感病毒1、2和3型(PIVS)和Q熱立克次體(COX),同時(shí)根據(jù)血?dú)夥治鰧?00名患者分成呼吸衰竭組（54例）和非呼吸衰竭組（146例），根據(jù)患者患者臨床表現(xiàn)、體征及生化指標(biāo)等，分析每種病原體的陽性率及兩組在呼吸道感染的陽性率。結(jié)果：AECOPD患者中，感染陽性者62例，總陽性率為31%（62/200），各病原體中病毒的感染率較高，其中IFB占13.5%（27/200），RSV占4%（8/200）, IFA占3.5%(7/200)，ADV占3%（6/200），PIVS占2%（4/200），在非典型病原體中，MP占7.5%（15/200），，LP占5%（10/200）, COX占0.5%（1/200）；合并呼吸衰竭是陽性率較非合并陽性率較高（P0.05）；同時(shí)合并2種病原體感染有9例，占陽性病例的14.5%，合并3種病原體的感染有4例，占陽性病例的2%。結(jié)論：呼吸道病原體感染是AECOPD的重要誘因，其中呼吸道病毒感染是最常見的病原體，AECOPD患者合并呼吸衰竭時(shí)病原體的陽性率較非合并呼吸衰竭高，同時(shí)AECOPD患者易有多重病原體的混合感染。
[Abstract]:Objective: to analyze the relationship between common pathogen infection of respiratory tract and (AECOPD) in acute exacerbation of chronic obstructive pulmonary disease (COPD) and its effect on blood gas analysis. Methods: from February 2011 to February 2013, the serum samples of 200 patients with AECOPD in respiratory department of our hospital were detected by respiratory tract test reagent (indirect immunofluorescence method) to detect IgM antibodies against 9 major pathogens, including influenza A virus (IFA),. Type B influenza virus (IFB), Legionella pneumophils (LP), chlamydia pneumoniae (CP), mycoplasma pneumoniae (MP), respiratory syncytial virus (RSV), adenoviruses (ADV), Two hundred patients were divided into respiratory failure group (54 cases) and non-respiratory failure group (146cases) according to blood gas analysis. According to the clinical manifestations of parainfluenza virus 1, type 2 and type 3 (PIVS) and Q Rickettsia (COX), the patients were divided into respiratory failure group (n = 54) and non-respiratory failure group (n = 146) according to the clinical manifestations of the patients. The positive rate of each pathogen and the positive rate of respiratory tract infection in the two groups were analyzed. Results: among the patients with AECOPD, 62 cases were positive, the total positive rate was 31% (62 鈮

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