【摘要】：目的探討肺表面活性物質(zhì)蛋白(SP)相關(guān)基因多態(tài)性與慢性阻塞性肺疾病(COPD)的關(guān)聯(lián)。方法檢索萬方數(shù)據(jù)、維普、Google學(xué)術(shù)、PubMed、CNKI、CBM、EMBASE、Web of Science等電子數(shù)據(jù)庫,檢索范圍從建庫至2013年9月,采用Stata12.0進行Meta分析。結(jié)果本研究共計納入7項病例對照研究,包括1279例COPD患者和1482名健康對照人群。SP-A基因多態(tài)性與COPD易感性增加有關(guān)(等位基因模型OR=1.53,95%CI:1.14~2.05,P=0.005;顯性模型OR=1.65,95%CI:1.02~2.69,P=0.043;隱性模型OR=1.66,95%CI:1.17~2.35,P=0.005;純合子模型OR=2.06,95%CI:1.24~3.41,P=0.005;雜合子模型OR=1.59,95%CI:1.13~2.22,P=0.007),但SP-B和SP-D基因多態(tài)性均與COPD易感性關(guān)聯(lián)無統(tǒng)計學(xué)意義(均P0.05)。亞組分析表明,SP-A基因多態(tài)性與亞洲人群COPD易感性增加關(guān)系密切,但與歐美人群無關(guān)。結(jié)論 SP-A基因多態(tài)性可能與亞洲人群COPD易感性增加有關(guān)。
[Abstract]:Objective to investigate the association between pulmonary surfactant protein (SP)-associated gene polymorphism and chronic obstructive pulmonary disease (COPD) (COPD). Methods the electronic databases, such as Wanfang data, Vip, Google academic and PubMed,CNKI,CBM,EMBASE,Web of Science, were retrieved from September 2013 to September 2013. Meta analysis was carried out by Stata12.0. Results this study included 7 case-control studies, including 1279 COPD patients and 1482 healthy controls. Sp-A gene polymorphism was associated with increased susceptibility to COPD (allele model OR=1.53,95%CI:1.14~2.05,P=0.005;). Dominant model OR=1.65,95%CI:1.02~2.69,P=0.043; recessive model OR=1.66,95%CI:1.17~2.35,P=0.005; homozygote model OR=2.06,95%CI:1.24~3.41,P=0.005; Heterozygote model OR=1.59,95%CI:1.13~2.22,P=0.007), but there was no significant correlation between SP-B and SP-D gene polymorphism and susceptibility to COPD (P0.05). Subgroup analysis showed that SP-A gene polymorphism was closely associated with increased susceptibility to COPD in Asian population, but not with European and American population. Conclusion SP-A gene polymorphism may be associated with increased susceptibility to COPD in Asian population.
【作者單位】： 大連醫(yī)科大學(xué)附屬第一醫(yī)院呼吸內(nèi)科;大連大學(xué)附屬中山醫(yī)院;大連醫(yī)科大學(xué)附屬第一醫(yī)院消化內(nèi)科;
【基金】：遼寧省教育廳科技研究項目(No.ZX13017)
【分類號】：R563.9
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本文編號：2455156