【摘要】：目的:研究扶肺固腎膏對(duì)慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)穩(wěn)定期肺腎氣陰兩虛痰淤證BODE指數(shù)的影響,評(píng)價(jià)扶肺固腎膏治療COPD的療效。方法:按照課題設(shè)計(jì)的納入和排除標(biāo)準(zhǔn),收集60例符合COPD診斷的穩(wěn)定期患者,隨機(jī)平均分為兩組,對(duì)照組和治療組,對(duì)照組(舒利迭組)和治療組(舒利迭加扶肺固腎膏組),對(duì)照組予舒利迭治療,治療組在對(duì)照組治療基礎(chǔ)上口服扶肺固腎膏,療程3個(gè)月。治療前后分別測試兩組患者的BODE指數(shù),將所有數(shù)據(jù)建立數(shù)據(jù)庫,運(yùn)用統(tǒng)計(jì)軟件進(jìn)行分析,對(duì)比兩組患者治療前后BODE指數(shù)各個(gè)變量及BODE總分的改變。結(jié)果:1、兩組患者治療前后比較:兩組患者治療后與治療前相比,第一秒用力呼氣容積占預(yù)計(jì)值百分比(FEV1%pred)、6分鐘步行距離(6MWD)均明顯增加,差異有統(tǒng)計(jì)學(xué)意義(P0.05),呼吸困難問卷(mMRC)、BODE指數(shù)評(píng)分較治療前明顯下降,差異有統(tǒng)計(jì)學(xué)意義(P0.05),兩組患者體質(zhì)指數(shù)(BMI)在治療前后差異無統(tǒng)計(jì)學(xué)意義(P0.05)。2、兩組患者治療后組間比較:兩組患者經(jīng)治療后,治療組的FEV1%pred、6MWD升高較對(duì)照組明顯,差異有統(tǒng)計(jì)學(xué)意義(P0.05),治療組的mMRC、BODE指數(shù)評(píng)分下降較對(duì)照組明顯,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:扶肺固腎膏配合吸入激素能明顯提高COPD穩(wěn)定期中醫(yī)證型屬肺腎氣陰兩虛痰淤證患者的FEV1%pred、6MWD,降低患者mMRC、BODE指數(shù)評(píng)分,臨床上用藥安全,值得推廣使用。
[Abstract]:Objective: to study the effect of Fufei Gushen ointment on BODE index of stable lung and kidney qi and yin deficiency and phlegm stasis syndrome in patients with chronic obstructive pulmonary disease (Chronic obstructive pulmonary disease,COPD), and to evaluate the curative effect of Fu Fei Gu Shen ointment on COPD. Methods: according to the designed criteria of inclusion and exclusion, 60 stable patients diagnosed by COPD were randomly divided into two groups: control group and treatment group, control group (sulidide group) and treatment group (Sulidi plus Fufei Gushen ointment group). The control group was treated with sulidide, and the treatment group was treated with Fufei Gu Shen ointment for 3 months. The BODE index of two groups of patients was tested before and after treatment, and all the data were set up and analyzed by statistical software. The changes of BODE index and BODE total score before and after treatment were compared between the two groups. Results: 1. Comparison between the two groups before and after treatment: after treatment, forced expiratory volume in the first second (FEV1%pred) and 6-minute walking distance (6MWD) were significantly increased in both groups compared with those before treatment. The difference was statistically significant (P0.05). The (mMRC), BODE index score of dyspnea questionnaire was significantly lower than that before treatment (P0.05). There was no significant difference in body mass index (BMI) between the two groups before and after treatment (P0.05). The comparison between the two groups after treatment: after treatment, the FEV1%pred,6MWD in the treatment group was significantly higher than that in the control group. The difference was statistically significant (P0.05). The mMRC,BODE index score of the treatment group was significantly lower than that of the control group (P0.05). Conclusion: Fufei Gushen ointment combined with inhaled hormone can obviously improve the FEV1%pred,6MWD, of patients with stable COPD syndrome of lung and kidney qi and yin deficiency and phlegm stasis. It is safe to use drugs clinically and is worth popularizing.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R563.9

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