【摘要】：目的探討哮喘-慢阻肺重疊綜合征患者的臨床特征。方法采用基于醫(yī)療信息數(shù)據(jù)庫(kù)的回顧性隊(duì)列研究方法,調(diào)取接受治療隨訪1年以上,固定氣流受限患者信息,按照哮喘、慢阻肺,以及新版2014年哮喘-慢阻肺重疊綜合征(asthma and chronic obstructive pulmonary disease overlap syndrome,ACOS)聯(lián)合指南的標(biāo)準(zhǔn)形成三組患者隊(duì)列,統(tǒng)計(jì)隊(duì)列中ACOS患者的比例、年齡分布;分析比較患者末次隨訪的氣道炎癥細(xì)胞、肺功能及年化FEV1下降率等臨床特征。結(jié)果 240例初診特征符合研究標(biāo)準(zhǔn)的患者被納入分析,按新指南標(biāo)準(zhǔn)分組發(fā)現(xiàn)ACOS患者比例為29.17%,以40歲以上年齡患者為主(88.57%),男性患者(61.40%)略多于女性患者,78.58%的患者支氣管舒張后第1秒用力肺活量占預(yù)計(jì)值的比例(post FEV1%pre)在50%以上,其性別組成、中位年齡、肺功能、氣道嗜酸性粒細(xì)胞炎癥患者比例與哮喘患者和慢阻肺患者比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05),具體數(shù)值介于哮喘患者和慢阻肺患者之間。未來(lái)風(fēng)險(xiǎn)評(píng)估提示雖然ACOS患者年化FEV1下降率與哮喘、慢阻肺患者差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),但下降的絕對(duì)值最大;而且中、重度年化急性加重的發(fā)生率也與慢阻肺患者相似,顯著高于哮喘患者(P0.01)。結(jié)論 ACOS患者的臨床特征介于哮喘、慢阻肺之間,而其未來(lái)風(fēng)險(xiǎn)更接近于慢阻肺。
[Abstract]:Objective to investigate the clinical features of asthmatic-chronic obstructive pulmonary overlap syndrome. Methods A retrospective cohort study based on medical information database was used to collect the information of patients with airflow limitation who were followed up for more than one year according to asthma and chronic obstructive pulmonary disease (COPD). And the new 2014 guidelines for asthmatic / chronic obstructive pulmonary overlap syndrome (asthma and chronic obstructive pulmonary disease overlap syndrome,ACOS) combined to form a cohort of three groups of patients, counting the proportion and age distribution of ACOS patients in the cohort; The clinical features of airway inflammatory cells, pulmonary function and annual FEV1 were analyzed and compared. Results 240 patients who met the study criteria were included in the analysis. According to the new guidelines, the proportion of patients with ACOS was 29.17, mainly over 40 years old (88.57%). Male patients (61.40%) were slightly more than female patients, 78.58% of the patients had forced vital capacity (post FEV1%pre) over 50% of the predicted value in 1 second after bronchodiastole. The proportion of airway eosinophils in patients with airway eosinophils was significantly higher than that in asthma and COPD patients (P0.05). The specific values were between asthmatic patients and COPD patients. Future risk assessment showed that although there was no significant difference in the annual FEV1 decline rate between ACOS patients and asthma and COPD patients (P0.05), the absolute value of the decrease was the largest. The incidence of severe acute exacerbation was similar to that of chronic obstructive pulmonary disease, significantly higher than that of asthmatic patients (P0.01). Conclusion the clinical features of ACOS patients are between asthma and COPD, and the future risk is closer to that of COPD.
【作者單位】： 第三軍醫(yī)大學(xué)新橋醫(yī)院全軍呼吸內(nèi)科研究所 全軍呼吸病研究重點(diǎn)實(shí)驗(yàn)室;
【基金】：“十二五”國(guó)家科技支撐計(jì)劃(2012BAI05B02,2014BAI08B05)~~
【分類號(hào)】：R562.25;R563.9

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 吳穎;萬(wàn)敏;張巧;李瑩;曾蘭;王長(zhǎng)征;馬千里;;導(dǎo)致新診斷慢性阻塞性肺疾病患者就診的主要原因及其氣道可逆程度觀察[J];中華肺部疾病雜志(電子版);2011年05期

2 張海琴;程齊儉;萬(wàn)歡英;;支氣管哮喘-慢性阻塞性肺疾病重疊綜合征的診治進(jìn)展[J];中國(guó)呼吸與危重監(jiān)護(hù)雜志;2014年02期

【共引文獻(xiàn)】

相關(guān)期刊論文 前6條

1 楊志仁;孫耕耘;;慢性阻塞性肺疾病患者對(duì)短效支氣管擴(kuò)張劑的急性舒張反應(yīng)[J];中華肺部疾病雜志(電子版);2013年04期

2 朱應(yīng)群;劉偉;張平;李U，

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