哮喘-慢阻肺重疊綜合征患者240例臨床特征分析
發(fā)布時間：2019-02-18 11:53
【摘要】：目的探討哮喘-慢阻肺重疊綜合征患者的臨床特征。方法采用基于醫(yī)療信息數(shù)據(jù)庫的回顧性隊列研究方法,調(diào)取接受治療隨訪1年以上,固定氣流受限患者信息,按照哮喘、慢阻肺,以及新版2014年哮喘-慢阻肺重疊綜合征(asthma and chronic obstructive pulmonary disease overlap syndrome,ACOS)聯(lián)合指南的標準形成三組患者隊列,統(tǒng)計隊列中ACOS患者的比例、年齡分布;分析比較患者末次隨訪的氣道炎癥細胞、肺功能及年化FEV1下降率等臨床特征。結(jié)果 240例初診特征符合研究標準的患者被納入分析,按新指南標準分組發(fā)現(xiàn)ACOS患者比例為29.17%,以40歲以上年齡患者為主(88.57%),男性患者(61.40%)略多于女性患者,78.58%的患者支氣管舒張后第1秒用力肺活量占預計值的比例(post FEV1%pre)在50%以上,其性別組成、中位年齡、肺功能、氣道嗜酸性粒細胞炎癥患者比例與哮喘患者和慢阻肺患者比較,差異有統(tǒng)計學意義(P0.05),具體數(shù)值介于哮喘患者和慢阻肺患者之間。未來風險評估提示雖然ACOS患者年化FEV1下降率與哮喘、慢阻肺患者差異無統(tǒng)計學意義(P0.05),但下降的絕對值最大;而且中、重度年化急性加重的發(fā)生率也與慢阻肺患者相似,顯著高于哮喘患者(P0.01)。結(jié)論 ACOS患者的臨床特征介于哮喘、慢阻肺之間,而其未來風險更接近于慢阻肺。
[Abstract]:Objective to investigate the clinical features of asthmatic-chronic obstructive pulmonary overlap syndrome. Methods A retrospective cohort study based on medical information database was used to collect the information of patients with airflow limitation who were followed up for more than one year according to asthma and chronic obstructive pulmonary disease (COPD). And the new 2014 guidelines for asthmatic / chronic obstructive pulmonary overlap syndrome (asthma and chronic obstructive pulmonary disease overlap syndrome,ACOS) combined to form a cohort of three groups of patients, counting the proportion and age distribution of ACOS patients in the cohort; The clinical features of airway inflammatory cells, pulmonary function and annual FEV1 were analyzed and compared. Results 240 patients who met the study criteria were included in the analysis. According to the new guidelines, the proportion of patients with ACOS was 29.17, mainly over 40 years old (88.57%). Male patients (61.40%) were slightly more than female patients, 78.58% of the patients had forced vital capacity (post FEV1%pre) over 50% of the predicted value in 1 second after bronchodiastole. The proportion of airway eosinophils in patients with airway eosinophils was significantly higher than that in asthma and COPD patients (P0.05). The specific values were between asthmatic patients and COPD patients. Future risk assessment showed that although there was no significant difference in the annual FEV1 decline rate between ACOS patients and asthma and COPD patients (P0.05), the absolute value of the decrease was the largest. The incidence of severe acute exacerbation was similar to that of chronic obstructive pulmonary disease, significantly higher than that of asthmatic patients (P0.01). Conclusion the clinical features of ACOS patients are between asthma and COPD, and the future risk is closer to that of COPD.
【作者單位】： 第三軍醫(yī)大學新橋醫(yī)院全軍呼吸內(nèi)科研究所 全軍呼吸病研究重點實驗室;
【基金】：“十二五”國家科技支撐計劃(2012BAI05B02,2014BAI08B05)~~
【分類號】：R562.25;R563.9
[Abstract]:Objective to investigate the clinical features of asthmatic-chronic obstructive pulmonary overlap syndrome. Methods A retrospective cohort study based on medical information database was used to collect the information of patients with airflow limitation who were followed up for more than one year according to asthma and chronic obstructive pulmonary disease (COPD). And the new 2014 guidelines for asthmatic / chronic obstructive pulmonary overlap syndrome (asthma and chronic obstructive pulmonary disease overlap syndrome,ACOS) combined to form a cohort of three groups of patients, counting the proportion and age distribution of ACOS patients in the cohort; The clinical features of airway inflammatory cells, pulmonary function and annual FEV1 were analyzed and compared. Results 240 patients who met the study criteria were included in the analysis. According to the new guidelines, the proportion of patients with ACOS was 29.17, mainly over 40 years old (88.57%). Male patients (61.40%) were slightly more than female patients, 78.58% of the patients had forced vital capacity (post FEV1%pre) over 50% of the predicted value in 1 second after bronchodiastole. The proportion of airway eosinophils in patients with airway eosinophils was significantly higher than that in asthma and COPD patients (P0.05). The specific values were between asthmatic patients and COPD patients. Future risk assessment showed that although there was no significant difference in the annual FEV1 decline rate between ACOS patients and asthma and COPD patients (P0.05), the absolute value of the decrease was the largest. The incidence of severe acute exacerbation was similar to that of chronic obstructive pulmonary disease, significantly higher than that of asthmatic patients (P0.01). Conclusion the clinical features of ACOS patients are between asthma and COPD, and the future risk is closer to that of COPD.
【作者單位】： 第三軍醫(yī)大學新橋醫(yī)院全軍呼吸內(nèi)科研究所 全軍呼吸病研究重點實驗室;
【基金】：“十二五”國家科技支撐計劃(2012BAI05B02,2014BAI08B05)~~
【分類號】：R562.25;R563.9
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