【摘要】：目的應(yīng)用豬尾導(dǎo)管建立能夠監(jiān)測(cè)血流動(dòng)力學(xué)變化的兔急性肺血栓栓塞(PTE)模型。方法試驗(yàn)兔24只隨機(jī)分為PTE組和對(duì)照組,每組12只,均建立右側(cè)頸靜脈和左側(cè)頸動(dòng)脈通路。PTE組經(jīng)導(dǎo)管注入自體血栓3個(gè),通過肺動(dòng)脈造影評(píng)估PTE模型是否成功,監(jiān)測(cè)肺動(dòng)脈壓力和血?dú)夥治龅茸兓�。結(jié)果造模成功率100%。PTE組肺動(dòng)脈造影顯示,右心室擴(kuò)張,肺動(dòng)脈增粗、充盈缺損、截?cái)嗷蛲耆笔АＴ炷：?PTE組較造模前和對(duì)照組肺動(dòng)脈平均壓明顯增高[(16.40±1.82)mm Hg vs(9.60±2.07)mm Hg和(11.17±2.14)mm Hg,1 mm Hg=0.133kPa,P=0.01,P=0.002]。血?dú)夥治鲲@示,造模后PTE組較造模前pH、PO2、標(biāo)準(zhǔn)碳酸氫鹽、血氧飽和度以及動(dòng)脈/肺泡氧分壓等指標(biāo)明顯降低,肺泡動(dòng)脈氧分壓差明顯增加。結(jié)論經(jīng)頸靜脈送入豬尾導(dǎo)管建立兔急性PTE模型成功率較高,重復(fù)性較好,且能夠監(jiān)測(cè)血流動(dòng)力學(xué)變化,為PTE診治的相關(guān)研究提供了實(shí)驗(yàn)基礎(chǔ)。
[Abstract]:Objective to establish a rabbit model of acute pulmonary thromboembolism (PTE) by using pig tail catheter to monitor hemodynamic changes. Methods Twenty-four rabbits were randomly divided into PTE group and control group, 12 in each group. The right jugular vein and left carotid artery were established in each group. 3 autologous thrombus were injected through catheter in PTE group. The success of PTE model was evaluated by pulmonary arteriography. Pulmonary artery pressure and blood gas analysis were monitored. Results Pulmonary arteriography showed right ventricular dilatation, pulmonary artery thickening, filling defect, amputation or complete deletion in 100%.PTE group. After modeling, the mean pulmonary artery pressure in PTE group was significantly higher than that before model making and control group [(16.40 鹵1.82) mm Hg vs (9.60 鹵2.07) mm Hg and (11.17 鹵2.14) mm Hg,1 mm Hg=0.133kPa,P=0.01,P=0.002]. Blood gas analysis showed that the pH,PO2, standard bicarbonate, blood oxygen saturation and arterial / alveolar partial pressure of oxygen in PTE group were significantly lower than those before model making, and the difference of oxygen pressure difference in alveolar artery was obviously increased. Conclusion the rabbit acute PTE model established through jugular vein into pig tail catheter has high success rate, good repeatability, and can monitor hemodynamic changes, which provides experimental basis for the study of diagnosis and treatment of PTE.
【作者單位】： 天津醫(yī)科大學(xué)心血管病臨床學(xué)院
【基金】：天津市濱海新區(qū)衛(wèi)生局醫(yī)藥衛(wèi)生科技(2011BHKY006)
【分類號(hào)】：R563.5

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