【摘要】：目的探討合肽素水平對(duì)呼吸衰竭患者預(yù)后的臨床意義,以更好地開展治療工作。方法選取2010年12月—2012年12月吉林省前衛(wèi)醫(yī)院呼吸科和吉林大學(xué)第一醫(yī)院急診科重癥監(jiān)護(hù)室收治的132例呼吸衰竭患者,檢測(cè)患者入院時(shí)的血清合肽素水平,并記錄各項(xiàng)實(shí)驗(yàn)室檢測(cè)指標(biāo)和臨床生理指標(biāo)。以28 d為終點(diǎn)比較存活組與死亡組患者的合肽素水平、急性生理學(xué)與慢性健康狀況評(píng)分系統(tǒng)Ⅱ(APACHEⅡ)評(píng)分和簡(jiǎn)化急性生理學(xué)評(píng)分系統(tǒng)Ⅱ(SAPSⅡ)評(píng)分;分析合肽素水平與28 d病死率的關(guān)系。結(jié)果 132例呼吸衰竭患者28 d內(nèi)共有41例病死,死亡組血清合肽素水平高于存活組,差異有統(tǒng)計(jì)學(xué)意義〔(44.5±9.0)pmol/L比(29.2±12.0)pmol/L,P0.01〕。合肽素水平與APACHEⅡ評(píng)分和SAPSⅡ評(píng)分均呈正相關(guān)(r值分別為0.562、0.550)。合肽素水平預(yù)測(cè)28 d病死率的受試者工作特征曲線(ROC曲線)下面積為0.840〔95%CI(0.772,0.907)〕,預(yù)測(cè)28 d病死率的最佳界值為34.5 pmol/L。血清合肽素34.5 pmol/L、APACHEⅡ評(píng)分17.5分和SAPSⅡ評(píng)分30.5分是預(yù)測(cè)呼吸衰竭患者28 d病死率的獨(dú)立危險(xiǎn)因素。結(jié)論合肽素水平是預(yù)測(cè)呼吸衰竭患者28 d病死率的獨(dú)立指標(biāo),其預(yù)測(cè)能力與APACHEⅡ評(píng)分和SAPSⅡ評(píng)分相近。
[Abstract]:Objective to investigate the clinical significance of peptide level in the prognosis of patients with respiratory failure. Methods from December 2010 to December 2012, 132 patients with respiratory failure were selected from Department of Respiratory, Department of Respiratory and Emergency Department, first Hospital of Jilin University. The laboratory indexes and clinical physiological indexes were recorded. At the end of 28 days, the levels of synpeptidin, acute physiology and chronic health status scoring system 鈪，

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