發(fā)布時(shí)間：2018-12-17 13:15

【摘要】：目的探討哮喘患者血清維生素D水平與病情控制程度及肺功能的關(guān)系。方法哮喘患者66例作為哮喘組、健康體檢者28例作為對(duì)照組,分別測(cè)定兩組25羥維生素D[25(OH)D]水平。對(duì)哮喘組患者測(cè)定肺功能,并進(jìn)行哮喘控制測(cè)試(ACT)評(píng)分。根據(jù)ACT評(píng)分將哮喘組分為控制組、部分控制組及未控制組。結(jié)果哮喘組血清25(OH)D水平明顯低于對(duì)照組(P0.01),控制組明顯高于未控制組(P0.05),部分控制組與控制組和未控制組比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)�？刂平M第1秒用力肺呼氣容積占肺活量百分比(FEV1%)預(yù)計(jì)值較部分控制組及未控制組均明顯升高,兩兩比較均具有統(tǒng)計(jì)學(xué)差異(P0.05)。部分控制組及未控制組維生素D缺乏所占比例均較高,而控制組維生素D正常所占比例較高。不同控制水平的哮喘患者間血清25(OH)D水平分布差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。哮喘患者25(OH)D與肺功能參數(shù)FEV1%預(yù)計(jì)值之間存在正相關(guān)(r=0.643,P0.01)。結(jié)論哮喘患者血清維生素D普遍偏低,且與病情控制程度及肺功能相關(guān)。
[Abstract]:Objective to investigate the relationship between serum vitamin D level and severity of disease control and pulmonary function in asthmatic patients. Methods 66 asthmatic patients were used as asthma group and 28 healthy persons as control group. The levels of 25 hydroxyvitamin D [25 (OH) D] were measured in two groups. Lung function was measured in asthmatic group and (ACT) score was measured by asthma control test. According to ACT score, asthma group was divided into control group, partial control group and uncontrolled group. Results the level of serum 25 (OH) D in asthma group was significantly lower than that in control group (P0.01), and that in control group was significantly higher than that in uncontrolled group (P0.05). There was no significant difference between control group and control group (P0.05). Forced expiratory volume as a percentage of vital capacity (FEV1%) in control group was significantly higher than that in partial control group and non-control group (P0.05). The proportion of vitamin D deficiency in partial control group and control group was higher than that in control group, but the normal proportion of vitamin D in control group was higher than that in control group. There was no significant difference in the distribution of serum 25 (OH) D levels among asthma patients with different control levels (P0.05). There was a positive correlation between 25 (OH) D and FEV1% predictive value of pulmonary function parameters in asthmatic patients (r = 0. 643, P 0. 01). Conclusion Vitamin D in serum of asthmatic patients is generally low, and it is related to the degree of disease control and pulmonary function.
【作者單位】： 吉林大學(xué)第一醫(yī)院呼吸內(nèi)科;
【分類(lèi)號(hào)】：R562.25

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