【摘要】：目的探討烏司他丁在急性呼吸窘迫綜合征(ARDS)發(fā)生中的預(yù)防作用。方法具有ARDS發(fā)生風(fēng)險(xiǎn)的患者59例,采用隨機(jī)數(shù)字表法分為觀察組和對(duì)照組,觀察組在基礎(chǔ)治療的基礎(chǔ)上加用烏司他丁治療。觀察連續(xù)用藥7 d后兩組患者的血?dú)庵笜?biāo)變化情況、C反應(yīng)蛋白(CRP)、白細(xì)胞介素(IL)-6及腫瘤壞死因子(TNF)-α表達(dá)水平,比較兩組患者ICU入住時(shí)間、機(jī)械通氣時(shí)間及28 d生存率、急性生理和慢性健康狀態(tài)(APACHE)Ⅱ評(píng)分及ARDS發(fā)生率。結(jié)果治療后,兩組患者血?dú)庵笜?biāo)(pH、PaO_2、PaCO_2、PaO_2/FiO_2)均較治療前升高,且觀察組PaO_2、PaO_2/FiO_2均高于對(duì)照組(P0.05);兩組患者TNF-α、IL-6、CRP均較治療前降低,且觀察組均低于對(duì)照組(P0.05)。治療后,觀察組APACHEⅡ評(píng)分、機(jī)械通氣時(shí)間和ICU入住時(shí)間均明顯低于對(duì)照組(P0.05)。觀察組ARDS發(fā)生率為10.00%,顯著低于對(duì)照組ARDS發(fā)生率34.48%(P0.05);兩組患者28 d生存率的差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論烏司他丁在改善重癥患者血?dú)庵笜?biāo)、降低炎癥反應(yīng)、提高臨床療效、降低ARDS發(fā)生風(fēng)險(xiǎn)等方面具有顯著的作用。
[Abstract]:Objective to investigate the preventive effect of ulinastatin on acute respiratory distress syndrome (ARDS). Methods 59 patients with risk of ARDS were randomly divided into observation group and control group. The observation group was treated with ulinastatin on the basis of basic treatment. The changes of blood gas index, the expression of C-reactive protein (CRP), interleukin (IL) 6 and tumor necrosis factor (TNF) 偽 were observed in the two groups after 7 days of continuous administration. The time of ICU stay in the two groups was compared. Mechanical ventilation time and 28 day survival rate, acute physiological and chronic health state (APACHE) 鈪，

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