NT-proBNP、CTn-I的聯(lián)合檢測(cè)在急診呼吸困難患者診治中的應(yīng)用
發(fā)布時(shí)間：2018-11-24 18:17
【摘要】：目的研究聯(lián)合檢測(cè)氨基末端B型鈉尿肽原(NT-proBNP)和心肌肌鈣蛋白-I(cTn-I)在急診呼吸困難患者診治中的作用。方法利用酶聯(lián)免疫熒光法對(duì)送診到本院急診室的719例呼吸困難患者進(jìn)行血漿NT-proBNP和cTn-I水平檢測(cè),比較心源性呼吸困難患者(主要為CHF患者)和非心源性呼吸困難患者血漿中NT-proBNP和cTn-I值的差別,并對(duì)檢測(cè)結(jié)果進(jìn)行統(tǒng)計(jì)分析。結(jié)果 285例心力衰竭患者(HF)血漿NT-proBNP中位數(shù)為4 218 ng/L(930 ng/L~13 225 ng/L),cTn-I中位數(shù)(四分位數(shù))為8.12μg/L(1.02μg/L~18.22μg/L),明顯高于434例非HF患者[NTproBNP中位數(shù)為123 ng/L(28 ng/L~509 ng/L)](P0.001),[cTn-I中位數(shù)為0.68μg/L(0.01μg/L~2.29μg/L)(P0.001)],差異具有統(tǒng)計(jì)學(xué)意義;血漿NT-proBNP診斷CHF的最佳閾值為900 ng/L,其敏感性為91%、特異性為86%,ROC曲線下面積為0.845,YOUDEN指數(shù)為0.77;聯(lián)合檢測(cè)NT-proBNP和cTn-I敏感性為99%,特異性為92%,優(yōu)于單項(xiàng)檢測(cè)。結(jié)論對(duì)于急診室送診的呼吸困難患者,及時(shí)進(jìn)行NT-proBNP和cTn-I水平的聯(lián)合檢測(cè)在診斷和治療中十分有價(jià)值。
[Abstract]:Objective to study the role of combined detection of amino-terminal B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTn-I) in emergency patients with dyspnea. Methods the plasma levels of NT-proBNP and cTn-I in 719 patients with dyspnea were detected by enzyme-linked immunofluorescence (Elisa). The differences of plasma NT-proBNP and cTn-I between patients with cardiogenic dyspnea (mainly CHF) and non-cardiogenic dyspnea were compared and the results were statistically analyzed. Results the median of plasma NT-proBNP and cTn-I were 4 218 ng/L (930 ng/L~13 225 ng/L) and 8.12 渭 g / L (1.02 渭 g/L~18.22 渭 g / L) in 285 patients with heart failure. It was significantly higher than that in patients without HF [the median of NTproBNP was 123 ng/L (28 ng/L~509 ng/L)] (P0. 001), and the median of cTn-I was 0. 68 渭 g / L (0. 01 渭 g/L~2.29 渭 g / L) (P0. 001). The difference was statistically significant. The best threshold for the diagnosis of CHF by plasma NT-proBNP was 900 ng/L,. The sensitivity was 91 ng/L, and the specificity was 86. The area under the curve of ROC was 0. 845 and the index of YOUDEN was 0. 77. The sensitivity of combined detection of NT-proBNP and cTn-I was 99g and the specificity was 92.It was superior to single detection. Conclusion the combined detection of NT-proBNP and cTn-I in time is very valuable in the diagnosis and treatment of dyspnea patients in emergency room.
【作者單位】： 義烏市中心醫(yī)院檢驗(yàn)科;
【分類號(hào)】：R446.6;R56;R541.6
，
本文編號(hào)：2354559
[Abstract]:Objective to study the role of combined detection of amino-terminal B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTn-I) in emergency patients with dyspnea. Methods the plasma levels of NT-proBNP and cTn-I in 719 patients with dyspnea were detected by enzyme-linked immunofluorescence (Elisa). The differences of plasma NT-proBNP and cTn-I between patients with cardiogenic dyspnea (mainly CHF) and non-cardiogenic dyspnea were compared and the results were statistically analyzed. Results the median of plasma NT-proBNP and cTn-I were 4 218 ng/L (930 ng/L~13 225 ng/L) and 8.12 渭 g / L (1.02 渭 g/L~18.22 渭 g / L) in 285 patients with heart failure. It was significantly higher than that in patients without HF [the median of NTproBNP was 123 ng/L (28 ng/L~509 ng/L)] (P0. 001), and the median of cTn-I was 0. 68 渭 g / L (0. 01 渭 g/L~2.29 渭 g / L) (P0. 001). The difference was statistically significant. The best threshold for the diagnosis of CHF by plasma NT-proBNP was 900 ng/L,. The sensitivity was 91 ng/L, and the specificity was 86. The area under the curve of ROC was 0. 845 and the index of YOUDEN was 0. 77. The sensitivity of combined detection of NT-proBNP and cTn-I was 99g and the specificity was 92.It was superior to single detection. Conclusion the combined detection of NT-proBNP and cTn-I in time is very valuable in the diagnosis and treatment of dyspnea patients in emergency room.
【作者單位】： 義烏市中心醫(yī)院檢驗(yàn)科;
【分類號(hào)】：R446.6;R56;R541.6
，
本文編號(hào)：2354559
本文鏈接：http://sikaile.net/yixuelunwen/huxijib/2354559.html
最近更新
教材專著
