【摘要】：目的探討不同嚴(yán)重程度的慢性阻塞性肺疾病(COPD)患者在不同干粉吸入器阻力狀態(tài)下的吸氣能力。方法將54例中老年COPD患者納入研究,采用In-Check DIAL屮吸氣峰流量儀,測定模擬準(zhǔn)納器屮阻力狀態(tài)下的吸氣峰流量(PIF-D)以及模擬都保屮阻力狀態(tài)下的吸氣峰流量(PIF-T),同時測定呼氣峰流量(PEF)以及舒張后肺功能。結(jié)果 1例(1.9%)COPD患者未能達到Diskus屮的最低吸氣流量(30 L/min)要求,12例(22.2%)未能達到Turbuhaler屮的最低吸氣流量(60 L/min)要求,兩組間比較差異有統(tǒng)計學(xué)意義(x2=10.581,P=0.001)。對于PIF-D,7.1%的Ⅳ級COPD患者低于理想吸氣流量,Ⅱ級和Ⅲ級的PIF-D均達到理想吸氣流量或以上,不同級別COPD患者的PIF-D分級分布情況無統(tǒng)計學(xué)差異(x2=5.665,P=0.226)。對于PIF-T,Ⅱ級、Ⅲ級、Ⅳ級的COPD患者的比例為11.8%、26.1%、28.6%,不同級別COPD患者的PIF-T分級分布情況差異無統(tǒng)計學(xué)意義(x2=3.222,P=0.521)。直線回歸分析表明,COPD患者PEF測定值與PIF-D和PIF-T測定值均呈正相關(guān)(r=0.584,r=0.478,P=0.01)。結(jié)論通過評價COPD患者的疾病嚴(yán)重程度,無法判斷患者是否真正有效地吸入藥物。In-Check DIAL吸氣峰流量儀可測定COPD患者在不同吸入器阻力狀態(tài)下吸氣流量,臨床醫(yī)生可根據(jù)患者的測定結(jié)果來為患者選用不同的吸入器,并開具合理的藥物處方,適于在臨床上推廣應(yīng)用。
[Abstract]:Objective to investigate the inspiratory capacity of (COPD) patients with different severity of COPD under different resistance of dry powder inhaler. Methods 54 middle-aged and aged patients with COPD were included in the study. The peak inspiratory flow rate was measured by In-Check DIAL. Inspiratory peak flow (PIF-D) and peak inspiratory flow (PIF-T) were measured under simulated quasi-capacitive resistance and at the same time the peak expiratory flow (PEF) and postdiastolic pulmonary function were measured. Results one case (1.9%) of COPD failed to meet the minimum inspiratory flow (30 L/min) requirement of Diskus, and 12 cases (22.2%) failed to meet the minimum inspiratory flow (60 L/min) requirement of Turbuhaler. The difference between the two groups was statistically significant (x2 + 10.581% P0. 001). For the patients with grade 鈪，

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