【摘要】：目的:觀察肺咳停合劑聯(lián)合阿斯美治療風(fēng)邪伏肺型感染后咳嗽患者的臨床療效,探討其作用機(jī)制,為中西醫(yī)結(jié)合治療風(fēng)邪伏肺型感染后咳嗽提供一定的臨床依據(jù)。方法:選取2015年1月至2016年12月武漢市第一醫(yī)院呼吸內(nèi)科門診就診的120例風(fēng)邪伏肺型感染后咳嗽患者作為研究對(duì)象。這些患者隨機(jī)分為西藥組、中藥組、中西藥聯(lián)合組。西藥組給予阿斯美(復(fù)方甲氧那明)治療,中藥組給予肺咳停合劑治療,中西藥聯(lián)合組給予肺咳停合劑和阿斯美(復(fù)方甲氧那明)治療,療程共10天,治療10天后觀察患者臨床療效,中醫(yī)單項(xiàng)癥狀積分變化以及中醫(yī)證候總積分變化,并對(duì)其安全性進(jìn)行評(píng)價(jià)。運(yùn)用統(tǒng)計(jì)學(xué)軟件分析這些臨床觀察指標(biāo)的統(tǒng)計(jì)學(xué)差異,比較阿斯美、肺咳停合劑、以及兩藥聯(lián)合在治療風(fēng)邪伏肺型感染后咳嗽的有效率及三者在治療咳嗽、咳痰、咽癢等方面的治療效果。結(jié)果:(1)臨床療效:西藥組治療后總有效率為68.4%,中藥組治療后總有效率為61.5%,中西藥聯(lián)合組治療后總有效率為83.8%,統(tǒng)計(jì)學(xué)分析,三組治療后總有效率差異有統(tǒng)計(jì)學(xué)意義(P0.05),中西藥聯(lián)合組療效顯著。(2)治療后中醫(yī)單項(xiàng)癥狀積分:三組治療后咳嗽、咳痰、咽癢癥狀積分均較治療前減少,具有統(tǒng)計(jì)學(xué)意義(P0.05);咳嗽癥狀積分減少順序?yàn)?中西藥聯(lián)合組西藥組中藥組,組間差異具有統(tǒng)計(jì)學(xué)意義(P0.05);咳痰癥狀積分減少順序?yàn)?中西藥聯(lián)合組中藥組西藥組,組間差異具有統(tǒng)計(jì)學(xué)意義(P0.05);咽癢癥狀積分減少順序,中西藥聯(lián)合組中藥組西藥組,組間差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。(3)治療后中醫(yī)證候總積分:三組治療后中醫(yī)證候總積分較治療前差異有統(tǒng)計(jì)學(xué)意義(P0.05);中西藥聯(lián)合組中醫(yī)證候總積分減少更為明顯,中藥組和西藥組中醫(yī)證候總積分差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:肺咳停合劑、阿斯美能夠改善風(fēng)邪伏肺型感染后咳嗽患者的臨床癥狀,兩藥聯(lián)合治療能更有效的緩解咳嗽咳痰癥狀,提高臨床療效。在臨床療效方面,肺咳停合劑與阿斯美療效相當(dāng)。肺咳停合劑聯(lián)合阿斯美能明顯緩解患者咳嗽、咳痰、咽癢等癥狀,治療風(fēng)邪伏肺型感染后咳嗽有較顯著的療效。
[Abstract]:Objective: to observe the clinical effect of Feiketing mixture (FKT) combined with Asmet in treating cough after wind-pathogenic lung infection, and to explore its mechanism, and to provide some clinical basis for the treatment of wind-pathogenic pulmonary infection with combined TCM and western medicine. Methods: from January 2015 to December 2016, 120 patients with cough after wind-induced pulmonary infection in Department of Respiratory Medicine, the first Hospital of Wuhan, were selected as study objects. These patients were randomly divided into western medicine group and combined Chinese and western medicine group. The western medicine group was treated with Asmectin (compound methoxifen), the traditional Chinese medicine group was treated with the Feiketan mixture, and the Chinese and western medicine combination group was treated with the combination of the Chinese medicine and the western medicine. The course of treatment was 10 days. After 10 days of treatment, the clinical efficacy, the change of TCM single symptom integral and the total score of TCM syndromes were observed, and the safety was evaluated. Statistical software was used to analyze the statistical differences of these clinical observation indexes, to compare the effective rate of Asmat, Feiketing mixture, and the combination of the two drugs in the treatment of lung type infection caused by wind evil, and to treat cough, expectoration and phlegm among the three groups. The therapeutic effect of pharynx itching and other aspects. Results: (1) Clinical efficacy: the total effective rate was 68.4 in the western medicine group, 61.5 in the traditional Chinese medicine group and 83.8 in the traditional Chinese medicine group. The total effective rate of the three groups after treatment was significantly different (P0.05), the curative effect of the combination group was significant. (2) after the treatment of TCM single symptom integral: the three groups after treatment cough, expectoration, pharyngitic itch symptom score were reduced compared with before treatment, The decrease order of cough symptom integral was: Chinese medicine group, western medicine group, Chinese medicine group, the difference was statistically significant (P0.05); expectoration symptom score reduction order was: traditional Chinese medicine group, western medicine group, Chinese medicine group, western medicine group and western medicine group, the order was: traditional Chinese medicine group, western medicine group, and western medicine group. The difference between the two groups was statistically significant (P0.05); the order of the decrease in the score of pharyngotic symptoms, the traditional Chinese medicine combined with western medicine group, the Western medicine group, the Chinese medicine group, the western medicine group, The difference between groups was statistically significant (P0.05). (3) after treatment of TCM syndromes total integral: the three groups after treatment TCM syndrome total score was statistically significant difference compared with before treatment (P0.05); traditional Chinese medicine combined with Chinese medicine syndromes total score decreased more significantly, There was no significant difference in the total score of TCM syndromes between the Chinese medicine group and the western medicine group (P0.05). Conclusion: Feiketing mixture and Asmex can improve the clinical symptoms of patients with cough after wind-induced lung infection. The combined treatment can relieve cough and expectoration more effectively and improve the clinical efficacy. In terms of clinical efficacy, Feiketing mixture and Asmectin have the same curative effect. The treatment of cough, expectoration, pharyngoitch and other symptoms with Feiketing mixture combined with asmetamine has a significant effect on cough after wind-induced pulmonary infection.
【學(xué)位授予單位】：湖北中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R56

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