【摘要】：目的了解肺癌患者姑息治療后肺部感染的病原菌分布及耐藥性,為醫(yī)院合理用藥提供參考依據(jù)。方法選擇2014年6月-2015年7月于醫(yī)院腫瘤內(nèi)科接受姑息治療過程中發(fā)生肺部感染的肺癌患者106例,收集患者痰液標本,進行細菌培養(yǎng)、鑒別及藥敏試驗,對病原菌的分布特點、類型及耐藥性進行分析,數(shù)據(jù)采用SPSS 17.0軟件進行統(tǒng)計分析。結果 106份標本中培養(yǎng)出病原菌174株,以革蘭陰性菌為主,共102株占58.62%;銅綠假單胞菌、肺炎克雷伯菌及大腸埃希菌對亞胺培南的耐藥率低,均20.00%;主要革蘭陽性菌對萬古霉素的耐藥率,均為0;主要真菌對酮康唑的耐藥率低,均為0。結論肺癌姑息治療合并肺部感染患者的病原菌以革蘭陰性菌為主,臨床應加強對革蘭陰性菌及其耐藥性檢測,在對癥治療的基礎上,需要建立完善的消毒滅菌機制,培養(yǎng)醫(yī)護人員的無菌操作意識,合理使用抗菌藥物,減少耐藥菌的產(chǎn)生。
[Abstract]:Objective to investigate the distribution of pathogenic bacteria and drug resistance of pulmonary infection after palliative treatment in patients with lung cancer, and to provide reference for rational use of drugs in hospitals. Methods 106 lung cancer patients who received palliative treatment from June 2014 to July 2015 were selected. The sputum samples were collected, bacteria culture, identification and drug sensitivity test were performed to analyze the distribution of pathogenic bacteria. Types and drug resistance were analyzed, and the data were analyzed by SPSS 17.0 software. Results 174 strains of pathogenic bacteria were isolated from 106 samples, 102 strains were Gram-negative bacteria, accounting for 58.62.The resistance rate of Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli to imipenem was low. The resistance rate of main gram-positive bacteria to vancomycin was 0, and the resistance rate of major fungi to ketoconazole was 0. Conclusion Gram-negative bacteria are the main pathogenic bacteria in patients with pulmonary infection after palliative treatment of lung cancer. The detection of Gram-negative bacteria and their drug resistance should be strengthened in clinic. On the basis of symptomatic treatment, it is necessary to establish a complete disinfection and sterilization mechanism. Cultivate the aseptic operation consciousness of medical staff, use antibiotics rationally and reduce the production of drug-resistant bacteria.
【作者單位】： 青海大學附屬醫(yī)院腫瘤內(nèi)科;
【基金】：青海省科技廳科研基金資助項目(2014ZJ737)
【分類號】：R734.2;R563.1

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