幽門螺桿菌感染與慢性阻塞性肺疾病關(guān)系的研究
發(fā)布時(shí)間：2018-09-16 20:08
【摘要】：目的：通過分析COPD患者血清細(xì)胞因子IL-6、IL-17、anti-Hp-IgG的變化，及與肺功能FEV1%預(yù)計(jì)值的相關(guān)性，探討幽門螺桿菌（Hp）感染與慢性阻塞性肺疾病（COPD）發(fā)病的相關(guān)性及可能作用機(jī)制。 方法：根據(jù)GOLD指南,通過臨床表現(xiàn)、肺功能測(cè)定確診COPD，使用支氣管擴(kuò)張劑后FEV1/FVC0.7，確定為持續(xù)性氣流受限從而診斷COPD，選取31例（男20例，女11例，平均年齡62.74±4.27）2011.12-2012.7經(jīng)我院門診檢查臨床確診的COPD穩(wěn)定期患者為COPD組，同時(shí)隨機(jī)選取2012年7月于我院體檢中心體檢性別、年齡相匹配的健康志愿者30例（男18例，女12例，平均年齡61.97±3.16）為對(duì)照組。所有入選者均進(jìn)行肺功能檢測(cè)，并于肺功能檢查的次日空腹抽取外周靜脈血5ml，分離血清,-70℃超低溫冰箱冷凍，統(tǒng)一采用ELISA方法檢測(cè)血清細(xì)胞因子IL-6、IL-17的水平和anti-Hp-IgG水平。 結(jié)果： (1)COPD組血清anti-Hp-IgG水平明顯高于對(duì)照組(P=0.042），且患者肺功能FEV1%預(yù)計(jì)值與anti-Hp-IgG水平呈負(fù)相關(guān)（r=-0.662,P0.001）; (2)COPD組血清IL-6、IL-17水平分別明顯高于對(duì)照組(P0.001,P=0.036)， (3)COPD組IL-17水平與anti-Hp-IgG水平呈正相關(guān)（r=0.671,P0.001）而與FEV1%預(yù)計(jì)值呈負(fù)相關(guān)（r=-0.615,P0.001）。 (4)COPD組IL-6水平與anti-Hp-IgG水平和肺功能FEV1%預(yù)計(jì)值沒有相關(guān)性。 結(jié)論：（1）Hp感染刺激血清IL-6、IL-17水平增高。 （2）COPD患者血清anti-Hp-IgG、IL-6、IL-17水平增高，且IL-17水平與anti-Hp-IgG呈正相關(guān)而與肺功能FEV1%預(yù)計(jì)值呈負(fù)相關(guān)。 （3）Hp感染促進(jìn)了COPD的進(jìn)展，兩者所啟動(dòng)的體內(nèi)炎癥反應(yīng)也許是兩者相互作用的機(jī)制，可能與IL-17激活有關(guān)。
[Abstract]:Objective: to investigate the relationship between Helicobacter pylori (Hp) infection and (COPD) in patients with chronic obstructive pulmonary disease (COPD) by analyzing the changes of serum cytokine IL-6,IL-17,anti-Hp-IgG and its correlation with FEV1% prediction of pulmonary function in patients with COPD. Methods: according to the GOLD guidelines, 31 cases (male 20, female 11) with COPD, were diagnosed as persistent airflow limitation after COPD, was confirmed by pulmonary function test after bronchiectasis. The average age was 62.74 鹵4.27. The stable COPD patients diagnosed by outpatient examination in our hospital from 12 to 2012.7 were selected as COPD group. 30 healthy volunteers (18 males and 12 females) who were examined in the physical examination center of our hospital in July 2012 were selected randomly. The average age was 61.97 鹵3.16). All the patients were tested for pulmonary function, and the peripheral venous blood was extracted from 5 ml on an empty stomach the next day after pulmonary function examination, and the serum was isolated and frozen in ultra-low temperature refrigerator at 70 鈩，
本文編號(hào)：2244652
[Abstract]:Objective: to investigate the relationship between Helicobacter pylori (Hp) infection and (COPD) in patients with chronic obstructive pulmonary disease (COPD) by analyzing the changes of serum cytokine IL-6,IL-17,anti-Hp-IgG and its correlation with FEV1% prediction of pulmonary function in patients with COPD. Methods: according to the GOLD guidelines, 31 cases (male 20, female 11) with COPD, were diagnosed as persistent airflow limitation after COPD, was confirmed by pulmonary function test after bronchiectasis. The average age was 62.74 鹵4.27. The stable COPD patients diagnosed by outpatient examination in our hospital from 12 to 2012.7 were selected as COPD group. 30 healthy volunteers (18 males and 12 females) who were examined in the physical examination center of our hospital in July 2012 were selected randomly. The average age was 61.97 鹵3.16). All the patients were tested for pulmonary function, and the peripheral venous blood was extracted from 5 ml on an empty stomach the next day after pulmonary function examination, and the serum was isolated and frozen in ultra-low temperature refrigerator at 70 鈩，
本文編號(hào)：2244652
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