【摘要】：目的探討針對(duì)急性肺部細(xì)菌性感染患者使用鹽酸左氧氟沙星序貫治療的臨床效果及不良反應(yīng)。方法選取2012年9月-2013年12月醫(yī)院急性肺部細(xì)菌性感染患者160例,對(duì)其送檢標(biāo)本進(jìn)行病原菌檢測,菌種鑒定采用法國生物梅里埃公司的VITEK-60全自動(dòng)細(xì)菌分析儀,藥物敏感試驗(yàn)采用方法是K-B紙片擴(kuò)散法;按數(shù)學(xué)隨機(jī)方法分為普通組和治療組,各80例,普通組使用鹽酸左氧氟沙星注射液治療,治療組使用鹽酸左氧氟沙星注射液及膠囊序貫方案治療,對(duì)比兩組治療效果及不良反應(yīng)。結(jié)果 160例感染患者培養(yǎng)分離出186株病原菌,革蘭陰性菌133株占71.51%,革蘭陽性菌53株占28.49%,肺炎克雷伯菌、銅綠假單胞菌、肺炎鏈球菌、不動(dòng)桿菌屬、金黃色葡萄球菌為主要菌種;治療有效率普通組患者為92.50%、治療組患者為92.50%,對(duì)比差異無統(tǒng)計(jì)學(xué)意義;不良反應(yīng)發(fā)生率普通組患者為3.75%、治療組患者為2.50%,兩組不良反應(yīng)發(fā)生率對(duì)比差異無統(tǒng)計(jì)學(xué)意義。結(jié)論針對(duì)急性肺部細(xì)菌性感染患者使用鹽酸左氧氟沙星注射液及膠囊序貫治療的臨床效果與僅使用鹽酸左氧氟沙星注射液治療的效果相近,序貫治療經(jīng)濟(jì)性較好且安全性更高,值得臨床推廣應(yīng)用。
[Abstract]:Objective to investigate the clinical effects and adverse reactions of levofloxacin hydrochloride (levofloxacin hydrochloride) in patients with acute pulmonary bacterial infection. Methods A total of 160 patients with acute pulmonary bacterial infection from September 2012 to December 2013 were selected and tested for pathogenic bacteria. The bacteria were identified by VITEK-60 automatic bacteria analyzer of French Bio-Meridier Company. The drug sensitivity test was conducted by K-B disk diffusion method, and was randomly divided into two groups, 80 cases in each group, and 80 cases in each group. The common group was treated with levofloxacin hydrochloride injection. The treatment group was treated with levofloxacin hydrochloride injection and capsule sequential regimen. Results 186 pathogenic bacteria were isolated from 160 infected patients, 133 Gram-negative bacteria accounted for 71.51 and 53 Gram-positive bacteria accounted for 28.49.The Klebsiella pneumoniae, Pseudomonas aeruginosa, Streptococcus pneumoniae, Acinetobacter spp., Staphylococcus aureus were the main strains. The effective rate of treatment was 92.50 in the general group and 92.50 in the treatment group. The incidence of adverse reactions was 3.75 in the common group and 2.50 in the treatment group. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion the clinical effect of levofloxacin hydrochloride injection and capsule sequential therapy for patients with acute pulmonary bacterial infection is similar to that of levofloxacin hydrochloride injection alone, and the sequential treatment is more economical and safer than that of levofloxacin hydrochloride alone. It is worth popularizing and applying in clinic.
【作者單位】： 遵義醫(yī)學(xué)院附屬醫(yī)院藥劑科;遵義醫(yī)學(xué)院附屬醫(yī)院呼吸科;遵義醫(yī)學(xué)院附屬醫(yī)院檢驗(yàn)科;
【基金】：高等學(xué)校博士學(xué)科科研基金資助項(xiàng)目(200802260009)
【分類號(hào)】：R563.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 ;Chemotherapy with laparoscope-assisted continuous circulatory hyperthermic intraperitoneal perfusion for malignant ascites[J];World Journal of Gastroenterology;2010年15期

2 Andrzej Dabrowski;Wojciech Kwasniewski;Tomasz Skoczylas;Wies，

本文編號(hào)：2237780