【摘要】：目的:探討慢性阻塞性肺疾病(COPD)穩(wěn)定期患者血清IL-6、IL-18、人克拉拉細(xì)胞分泌蛋白(CC16)水平變化與肺功能及慢阻肺評(píng)估測(cè)試(CAT)評(píng)分的關(guān)系。方法 :檢測(cè)COPD組200例和對(duì)照組100例血清IL-6、IL-18、CC16濃度,并完成肺功能檢查和CAT評(píng)分問(wèn)卷。在COPD組患者中,將肺功能為Ⅰ~Ⅱ級(jí)者作為A亞組,Ⅲ~Ⅳ級(jí)者作為B亞組;根據(jù)COPD組患者的CAT評(píng)分,將0≤CAT分≤20者作為C亞組,21≤CAT分≤40者作為D亞組。結(jié)果:(1)與對(duì)照組相比,COPD組血清IL-6、IL-18水平升高,而CC16水平降低(均P0.01)。(2)與A亞組比較,B亞組血清IL-6、IL-18水平升高,CC16水平降低(均P0.01)。(3)與C亞組相比,D亞組血清IL-6、IL-18水平升高(P0.01),CC16水平降低(P=0.08)。(4)相關(guān)性分析:COPD穩(wěn)定期患者FEV1%與血清IL-6、IL-18水平呈負(fù)相關(guān)(r=-0.765,r=-0.721,P0.01),而與血清CC16水平呈正相關(guān)(r=0.397,P0.01)。COPD患者血清CC16水平與血清IL-6、IL-18濃度均呈負(fù)相關(guān)性(r=-0.221,r=-0.279,P0.01),CAT評(píng)分與血清IL-6、IL-18濃度呈正相關(guān)(r=0.500,r=0.533,P0.01)。結(jié)論 :COPD穩(wěn)定期患者血清IL-6、IL-18水平升高,CC16水平降低,可能參與了COPD肺功能損傷,并可能與COPD患者生存質(zhì)量下降有關(guān)。
[Abstract]:Aim: to investigate the relationship between the level of serum IL-6,IL-18, human Clara cell secretory protein (CC16) and pulmonary function and (CAT) score of chronic obstructive pulmonary disease (COPD) in patients with chronic obstructive pulmonary disease (COPD). Methods: the concentration of serum IL-6,IL-18,CC16 was measured in 200 cases of COPD group and 100 cases of control group. Pulmonary function test and CAT score questionnaire were completed. In the COPD group, the patients with grade 鈪，

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