【摘要】：目的探討血清網(wǎng)膜素-1水平與2型糖尿病并慢性阻塞性肺疾病(COPD)患者的關(guān)系。方法選取2型糖尿病合并COPD組,單純2型糖尿病組和正常對照組共143例患者,測定血清網(wǎng)膜素-1水平,并觀察血清網(wǎng)膜素-1與腰臀比、體質(zhì)指數(shù)(BMI)、血糖、血漿胰島素、血脂的關(guān)系,穩(wěn)態(tài)模式評估胰島素抵抗指數(shù)(HOMA-IR)。結(jié)果 2型糖尿病合并COPD患者和單純2型糖尿病患者網(wǎng)膜素-1水平均明顯低于對照組(P0.01),血清網(wǎng)膜素-1與HDL-C呈正相關(guān)(P0.01)。網(wǎng)膜素-1與BMI、腰臀比、DBP、FPG、TG、HOMAIR、HbA1C呈明顯負(fù)相關(guān)(P0.05或P0.01);多元線性逐步回歸分析表明,BMI、DBP、HOMA-IR是影響網(wǎng)膜素-1的因素(P0.05或P0.01)。結(jié)論網(wǎng)膜素-1可能涉及了胰島素抵抗和2型糖尿病合并慢性阻塞性肺疾病患者的發(fā)病機(jī)制。
[Abstract]:Objective to investigate the relationship between serum omentin-1 level and type 2 diabetes mellitus with chronic obstructive pulmonary disease (COPD). Methods A total of 143 patients with type 2 diabetes mellitus complicated with COPD, simple type 2 diabetes mellitus and normal control group were selected to measure the level of omentin-1 in serum, the ratio of omentin-1 to waist to hip, body mass index (BMI),) blood glucose and plasma insulin. The relationship between blood lipids and homeostasis model for evaluating insulin resistance index (HOMA-IR). Results the levels of omentin-1 in type 2 diabetes mellitus with COPD and simple type 2 diabetes mellitus were significantly lower than those in control group (P0.01). The serum omentin-1 level was positively correlated with HDL-C (P0.01). There was a significant negative correlation between omentin-1 and BMI, WHR (P0.05 or P0.01), and multiple linear stepwise regression analysis showed that HOMA-IR was a factor affecting omentin-1 (P0.05 or P0.01). Conclusion Retinin-1 may be involved in the pathogenesis of insulin resistance and type 2 diabetes with chronic obstructive pulmonary disease.
【作者單位】： 廣西桂林市人民醫(yī)院綜合內(nèi)科;
【分類號】：R587.1;R563.9

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王香,邵萍,牛文明,徐克煒;阻塞型睡眠呼吸暫停綜合征與胰島素抵抗的關(guān)系[J];臨床內(nèi)科雜志;2002年03期

2 李沖;韓書芝;平芬;李萍;李琪;;阻塞性睡眠呼吸暫停低通氣綜合征與胰島素抵抗的研究進(jìn)展[J];新醫(yī)學(xué);2010年10期

3 黃芬;蔣鈺;朱厚珍;李春明;;慢性阻塞性肺疾病與胰島素抵抗的臨床研究[J];山東大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2009年11期

4 喬珊;孫艷蓀;李雪梅;;持續(xù)氣道正壓通氣治療對OSAHS患者胰島素抵抗的影響[J];昆明醫(yī)學(xué)院學(xué)報(bào);2011年06期

5 武焱e，

本文編號：2209104