【摘要】：目的探討人類白細(xì)胞抗原(HLA)-DQA1位點(diǎn)基因多態(tài)性與塵肺病發(fā)病的相關(guān)性。方法采用1∶1配比的病例-對照研究方法,選取130例已確診為塵肺病的患者作為塵肺組,另選130例與塵肺組年齡和累計接塵工齡相近、同性別、同民族、同一工作地點(diǎn)的健康接塵工人作為對照組。用多重聚合酶鏈反應(yīng)-連接酶檢測反應(yīng)分型法,檢測2組研究對象HLA-DQA1共6個位點(diǎn)的等位基因,并分析其與塵肺病的相關(guān)性。結(jié)果塵肺組HLA-DQA1*0201和HLA-DQA1*0601基因頻率均高于對照組(14.62%vs 8.85%,12.69%vs 7.31%),而HLA-DQA1*0101基因頻率低于對照組(34.23%vs 43.08%),差異均有統(tǒng)計學(xué)意義(P0.05)。Logistic回歸分析顯示,HLA-DQA1*0101、HLA-DQA1*0201和HLA-DQA1*0601等位基因頻率與塵肺病有關(guān)聯(lián)(P0.05),優(yōu)勢比分別為0.688、1.764和1.844,95%可信區(qū)間分別為(0.482~0.981)、(1.018~3.055)和(1.019~3.336)。結(jié)論 HLA-DQA1*0201和HLA-DQA1*0601基因可能是塵肺病的易感基因,HLA-DQA1*0101基因可能是塵肺病的保護(hù)基因。
[Abstract]:Objective to investigate the relationship between (HLA) -DQA1 locus polymorphism of human leukocyte antigen and pneumoconiosis. Methods 130 patients with pneumoconiosis were selected as pneumoconiosis group by using the 1:1 matched case-control study, and 130 patients with pneumoconiosis were selected as the same age and cumulative exposure age, same sex and same nationality. Healthy workers exposed to dust in the same workplace served as the control group. Multiplex polymerase chain reaction-ligase assay was used to detect the alleles of 6 HLA-DQA1 loci in two groups of subjects, and the correlation between the alleles and pneumoconiosis was analyzed. Results the frequencies of HLA-DQA1*0201 and HLA-DQA1*0601 genes in pneumoconiosis group were higher than those in control group (14.62%vs 8.85: 12.69 vs 7.31%), while the frequency of HLA-DQA1*0101 gene was lower than that in control group (34.23%vs 43.08%). The difference was statistically significant (P0.05). Logistic regression analysis showed that the allele frequencies of HLA-DQA1-0101 HLA-DQA1-0201 and HLA-DQA1*0601 were associated with pneumoconiosis (P0.05). The confidence intervals of 0.688), (1.764 and 1.844V 95% were (0.482n) 0.981), (1.018 / 3.055 and (1.019 / 3.336), respectively. Conclusion HLA-DQA1*0201 and HLA-DQA1*0601 genes may be the susceptible genes of pneumoconiosis, and HLA-DQA1O101 gene may be a protective gene for pneumoconiosis.
【作者單位】： 山東省醫(yī)學(xué)科學(xué)院山東省腫瘤醫(yī)院;濟(jì)南大學(xué)山東省醫(yī)學(xué)科學(xué)院醫(yī)學(xué)與生命科學(xué)學(xué)院;淄博市職業(yè)病防治院;
【分類號】：R135.2

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