【摘要】：目的：探討內(nèi)源性硫化氫(H_2S)在急性高原肺水腫患者血漿中的表達(dá)及意義。 方法：通過采用敏感硫電極法測定（PXS-270型，上海雷磁）進(jìn)入玉樹地區(qū)(海拔3600米)急性高原肺水腫患者（病例組）38人（高原肺水腫32例、高原腦水腫合并肺水腫6例，均為移居男性，從事重體力勞動(dòng)）和進(jìn)入玉樹地區(qū)健康者（對照組）35人（均為男性）血漿H_2S的含量，對數(shù)據(jù)進(jìn)行整理并行統(tǒng)計(jì)學(xué)分析。統(tǒng)計(jì)方法：使用SPSS17.0統(tǒng)計(jì)學(xué)軟件對資料進(jìn)行分析，健康者及治療前后患者血漿H_2S均采用x±s表示，組間均數(shù)比較采用t檢驗(yàn)及單因素方差分析。檢驗(yàn)水準(zhǔn)取a=0.05。 結(jié)果：1.急性高原肺水腫患者治療前后血漿H_2S濃度差異有統(tǒng)計(jì)學(xué)意義t=8.219，P 0.01)，患者治療前血漿H_2S濃度水平略低于治療后。2.急性高原肺水腫患者與健康對照組血漿H_2S濃度差異有統(tǒng)計(jì)學(xué)意義（F=188.951，P 0.01)，，患者治療前后血漿H_2S濃度水平均低于健康對照組。 結(jié)論：1.急性高原肺水腫患者血漿H_2S濃度低于健康對照組。2.急性高原肺水腫患者治療前血i}h2S濃度低于治療后。
[Abstract]:Objective: to investigate the expression and significance of endogenous hydrogen sulfide (H 2S) in plasma of patients with acute high altitude pulmonary edema. Methods: 38 patients (case group) with acute high altitude pulmonary edema (3600 meters above sea level) in Yushu area (3600 meters above sea level) were detected by sensitive sulfur electrode method (PXS-270 type, Shanghai thunder magnetic field). 32 cases of high altitude pulmonary edema and 6 cases of high altitude brain edema complicated with pulmonary edema were studied. The plasma H2S contents of 35 healthy persons (all male) and 35 healthy persons (control group) in Yushu area were collected and analyzed statistically. Methods: SPSS17.0 software was used to analyze the data. The plasma H2S in healthy subjects and patients before and after treatment were expressed as x 鹵s, and the mean values were analyzed by t test and single factor analysis of variance (ANOVA). The inspection level is 0. 05%. The result is 1: 1. Before and after treatment, there was significant difference in plasma H2S concentration between patients with acute high altitude pulmonary edema (t = 8.219p 0.01), and the plasma H2S level before treatment was slightly lower than that after treatment (P < 0.01). There was significant difference in plasma H2S concentration between patients with acute high altitude pulmonary edema and healthy control group (P 0.01). The plasma H2S concentration of patients before and after treatment was lower than that of healthy control group. Conclusion 1. Plasma H2S concentration in patients with acute high altitude pulmonary edema was lower than that in healthy controls. The blood I} H 2S concentration in patients with acute high altitude pulmonary edema before treatment was lower than that after treatment.
【學(xué)位授予單位】：青海大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R563

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1 惠龍華;蔡尚郎;尹洪金;;原發(fā)性高血壓患者血漿H_2S測定及臨床意義[J];實(shí)用醫(yī)藥雜志;2006年01期

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