發(fā)布時(shí)間：2018-07-10 17:36

  本文選題：左氧氟沙星 + 肺結(jié)核　； 參考：《中國生化藥物雜志》2014年07期

【摘要】：目的通過meta分析研究左氧氟沙星治療難治性肺結(jié)核咯血的有效性和安全性。方法運(yùn)用計(jì)算機(jī)檢索Pubmed(2000/2014-07)、EMbase(2000/2014-07)、Cochrane圖書館(2014年第7期)、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(2000/2014-07)中關(guān)于左氧氟沙星治療難治性肺結(jié)核咯血的隨機(jī)對(duì)照試驗(yàn),將檢索時(shí)限定為2000年1月~2014年7月。經(jīng)對(duì)檢索到的論文進(jìn)行客觀的評(píng)價(jià)質(zhì)量后,應(yīng)用Cochrane協(xié)作網(wǎng)提供的Rev Man 5.3軟件系統(tǒng)進(jìn)行Meta分析。結(jié)果在6篇報(bào)道痰菌陰轉(zhuǎn)率中,左氧氟沙星組較對(duì)照組明顯增高,差異有統(tǒng)計(jì)學(xué)意義(OR=4.21,95%CI:3.08~5.75,P0.0001);對(duì)不良反應(yīng)報(bào)道的3篇文章,均示實(shí)驗(yàn)組和對(duì)照組不良反應(yīng)發(fā)生率無差異,無統(tǒng)計(jì)學(xué)意義(OR=0.82,95%CI:0.56~1.18,P=0.28)。結(jié)論采用左氧氟沙星對(duì)治療難治性肺結(jié)核咯血臨床療效顯著,安全性較高,對(duì)臨床具有指導(dǎo)意義,值得臨床推廣。
[Abstract]:Objective to study the efficacy and safety of levofloxacin in the treatment of refractory pulmonary tuberculosis hemoptysis by meta analysis. Methods A randomized controlled trial of levofloxacin for refractory pulmonary tuberculosis hemoptysis was searched by computer in Pubmed (2000 / 2014-07) / EMbase (2000 / 2014-07) / Cochrane Library (issue 7, 2014), Chinese Biomedical Literature Database (2000 / 2014-07), and limited to January 2000 to July 2014. After an objective evaluation of the quality of the retrieved papers, Meta-analysis was carried out using the Rev Man 5.3 software system provided by the Cochrane Cooperative Network. Results the sputum negative conversion rate in levofloxacin group was significantly higher than that in control group (ORO 4.21% 95 CI: 3.085.75% P0.0001), and there was no difference in the incidence of adverse reactions between experimental group and control group. There was no statistical significance (OR 0.82 / 95 CI: 0.56 / 1.18 / P0. 28). Conclusion levofloxacin is effective and safe in the treatment of hemoptysis of refractory pulmonary tuberculosis.
【作者單位】： 淮安第四人民醫(yī)院結(jié)核科;
【基金】：衛(wèi)生部醫(yī)藥科技發(fā)展研究中心項(xiàng)目(W2013R39)
【分類號(hào)】：R521

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 林青;林靜;;左氧氟沙星治療耐多藥肺結(jié)核的療效和不良反應(yīng)[J];當(dāng)代醫(yī)學(xué);2012年29期

2 陳明朝;楊松華;王偉;李莉;鄒月明;;氟喹諾酮類藥物治療老年初治肺結(jié)核療效觀察[J];海南醫(yī)學(xué);2009年02期

3 J.L.Johnson;D.J.Hadad;W.H.Boom;C.L.Daley;C.A.Peloquin;K.D.Eisenach;D.D.Jankus;S.M.Debanne;E.D.Charlebois;E.Maciel;M.Palaci;R.Dietzet;馬s，

本文編號(hào)：2114108