本文選題：鴿飼養(yǎng)者肺 + 白細(xì)胞介素�。� 參考：《中國(guó)全科醫(yī)學(xué)》2014年32期

【摘要】：目的探討維吾爾族飼?shū)澱叻?PBL)患者支氣管肺泡灌洗液(BALF)與血清中白介素(IL)-2、IL-10、腫瘤壞死因子-α(TNF-α)水平的變化及其在PBL發(fā)病機(jī)制中的作用。方法選取2012—2013年在新疆(喀什、和田)地區(qū)至少飼養(yǎng)鴿子1年以上的維吾爾族受試者,將新疆維吾爾自治區(qū)人民醫(yī)院呼吸科確診為PBL的受試者65例作為病例組,未患PBL的受試者120例作為陰性對(duì)照組;選取同期體檢健康的未飼?shū)澋木S吾爾族受試者120例為正常對(duì)照組。采用酶聯(lián)免疫吸附試驗(yàn)(ELISA)檢測(cè)3組受試者BALF與血清中IL-2、IL-10、TNF-α水平。結(jié)果病例組BALF與血清中IL-2、TNF-α的表達(dá)水平均較陰性對(duì)照組、正常對(duì)照組升高,陰性對(duì)照組較正常對(duì)照組亦升高(P0.05)。病例組、陰性對(duì)照組BALF與血清中IL-10的表達(dá)水平較正常對(duì)照組均降低(P0.05),而病例組與陰性對(duì)照組間差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論維吾爾族PBL患者BALF與血清中IL-10水平降低,IL-2、TNF-α水平升高;IL-2、TNF-α可能參與了PBL的發(fā)生發(fā)展。
[Abstract]:Objective to investigate the changes of IL-10 and TNF- 偽 levels in bronchoalveolar lavage fluid (BALF) and serum of pigeon feeding pigeon (PBL) and their role in the pathogenesis of PBL. Methods the subjects of Uygur nationality who raised pigeons in Xinjiang (Kashi, Hotan) for at least one year from 2012 to 2013 were selected as the case group. 65 subjects diagnosed as PBL by respiratory department of Xinjiang people's Hospital of Uygur Autonomous region were selected as the case group. 120 subjects without PBL were selected as negative control group and 120 Uygur subjects without feeding pigeon as normal control group. Elisa was used to detect the levels of BALF and IL-10 TNF- 偽 in serum of the three groups. Results the expression levels of BALF and IL-2TNF- 偽 in serum of the case group were higher than those of the negative control group, while the expression of IL-2TNF- 偽 in the negative control group was higher than that in the normal control group. In the case group, the expression of BALF and IL-10 in serum in the negative control group was lower than that in the normal control group (P 0.05), but there was no significant difference between the case group and the negative control group. Conclusion the levels of BALF and serum IL-10 in Uygur patients with PBL may be involved in the occurrence and development of PBL.
【作者單位】： 石河子大學(xué)醫(yī)學(xué)院;新疆維吾爾自治區(qū)人民醫(yī)院呼吸與危重癥醫(yī)學(xué)科;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(81260003)
【分類號(hào)】：R563.9

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本文編號(hào)：1933515