本文選題：自噬 + 肺部炎癥性疾病��； 參考：《重慶醫(yī)科大學(xué)學(xué)報(bào)》2017年01期

【摘要】：自噬(autophagy)是細(xì)胞生物的一種基本特征,具有獨(dú)特的調(diào)控通路,它可以選擇性地降解特定的蛋白質(zhì)、細(xì)胞器以及入侵的細(xì)菌。一般認(rèn)為在病理生理狀態(tài)下,自噬是一種細(xì)胞的保護(hù)性反應(yīng)。近期研究發(fā)現(xiàn)在某些代謝性疾病、神經(jīng)退行性病變、感染及免疫等疾病中自噬卻發(fā)揮不同作用,在某些疾病中,抑制自噬會(huì)導(dǎo)致疾病加重,而某些疾病則反之,自噬的激活會(huì)導(dǎo)致疾病的發(fā)生發(fā)展。那么自噬在肺部炎癥疾病中有著什么樣的作用呢?本文就自噬在肺部炎癥性疾病中的研究新進(jìn)展作一綜述。
[Abstract]:Autophagyis is a basic feature of cellular biology and has a unique regulatory pathway that selectively degrades specific proteins organelles and invasive bacteria. Autophagy is generally considered to be a cellular protective response in pathophysiological conditions. Recent studies have found that autophagy plays a different role in some metabolic diseases, neurodegenerative diseases, infections and immune diseases. In some diseases, inhibition of autophagy can lead to the exacerbation of the disease, while in some diseases the opposite is true. Autophagy activation can lead to the development of the disease. So what's the role of autophagy in lung inflammation? This article reviews the recent advances in the study of autophagy in pulmonary inflammatory diseases.
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本文編號(hào)：1904846