本文選題：肺疾病 + 慢性阻塞性��； 參考：《中國全科醫(yī)學(xué)》2017年28期

【摘要】：目的了解慢性阻塞性肺疾病(COPD)患者的身體成分改變,并探討其合并肌肉減少癥的影響因素。方法選取2016年9—12月在錦州醫(yī)科大學(xué)附屬第一醫(yī)院就診的COPD患者96例為病例組;另于同期在本院體檢者中,選取性別、年齡與病例組相匹配的健康成年人52例為對照組。檢測并比較兩組身高、體質(zhì)量、BMI及身體成分情況;根據(jù)歐洲老年人肌肉減少癥工作組(EWGSOP)制定的標準,以骨骼肌指數(shù)、步速為判斷是否合并肌肉減少癥的指標,采用單因素Logistic回歸分析和多元逐步Logistic回歸分析探討COPD合并肌肉減少癥的影響因素。結(jié)果病例組男性體質(zhì)量、BMI、全身肌肉量、軀干肌肉量、雙上肢肌肉量、雙下肢肌肉量、四肢肌肉量、去脂體質(zhì)量、骨骼肌指數(shù)、去脂體質(zhì)指數(shù)低于對照組男性,差異有統(tǒng)計學(xué)意義(P0.05);病例組女性體質(zhì)量、BMI、全身肌肉量、軀干肌肉量、雙上肢肌肉量、雙下肢肌肉量、四肢肌肉量、去脂體質(zhì)量、骨骼肌指數(shù)低于對照組女性,差異有統(tǒng)計學(xué)意義(P0.05)。病例組肌肉減少癥發(fā)生率高于對照組,差異有統(tǒng)計學(xué)意義(P0.05)。單因素Logistic回歸分析結(jié)果顯示,年齡、病程、BMI是COPD合并肌肉減少癥的影響因素(P0.05);多元逐步Logistic回歸分析結(jié)果顯示,年齡、長期吸煙史、病程、BMI是COPD合并肌肉減少癥的影響因素(P0.05)。結(jié)論 COPD患者肌肉量和去脂體質(zhì)量明顯低于健康者;COPD患者易合并肌肉減少癥,高齡、長期吸煙、病程長、低BMI是其危險因素。
[Abstract]:Objective to investigate the changes of body composition in patients with chronic obstructive pulmonary disease (COPD) and explore the influencing factors. Methods Ninety-six COPD patients in the first affiliated Hospital of Jinzhou Medical University from September to December 2016 were selected as the case group, and 52 healthy adults who were matched by sex, age and the case group were selected as the control group in the same period. The height, body mass, BMI and body composition of the two groups were measured and compared. According to the EWGSOP standard, the skeletal muscle index and step speed were used to determine whether or not to be associated with myopenia. Univariate Logistic regression analysis and multiple stepwise Logistic regression analysis were used to investigate the influencing factors of COPD with myopenia. Results in the case group, the body weight of BMI, the body muscle volume, the trunk muscle volume, the upper limb muscle volume, the lower limb muscle volume, the fat-free body mass, the skeletal muscle index and the fat free body mass index were lower than those in the control group. The difference was statistically significant (P 0.05). The body mass of women in the case group was lower than that in the control group, and the body mass, trunk muscle volume, double upper limb muscle volume, lower limb muscle volume, fat-free body mass and skeletal muscle index were lower than those in the control group. The difference was statistically significant (P 0.05). The incidence of myopenia in the case group was higher than that in the control group (P 0.05). Univariate Logistic regression analysis showed that age and course of disease were the influencing factors of COPD with myopenia, and multiple stepwise Logistic regression analysis showed that age, long smoking history and course of disease were the influencing factors of COPD with myopenia. Conclusion muscle volume and fat-free body mass in COPD patients were significantly lower than those in healthy controls. The risk factors were elderly, long-term smoking, long course of disease and low BMI.
【作者單位】： 錦州醫(yī)科大學(xué)研究生學(xué)院;錦州醫(yī)科大學(xué)附屬第一醫(yī)院呼吸科;錦州醫(yī)科大學(xué)第一臨床學(xué)院;
【分類號】：R563.9

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