本文選題：肺疾病 + 慢性阻塞性　； 參考：《重慶醫(yī)學》2017年03期

【摘要】：目的觀察沙丁胺醇對煙熏致慢性阻塞性肺疾病(COPD)實驗兔模型單肺通氣后血清和肺泡灌洗液中白三烯B4(LTB4)濃度的影響。方法健康新西蘭大白兔18只分為正常組、COPD組、COPD+沙丁胺醇組,每組6只。除正常組以外的其他兩組均采用實驗組自行創(chuàng)造的方法構建了單純煙熏致COPD實驗兔模型。分別在給實驗兔行右主支氣管插管前(T0),插管后即刻(T1),插管后行單肺通氣30min(T2),插管后行單肺通氣60min(T3)采血測LTB4,行右主支氣管插管單肺通氣60min后處死實驗兔,解剖后取少量雙肺上葉作組織病理學觀察,取適量支氣管肺泡灌洗液測LTB4的濃度。結果 COPD組中實驗兔支氣管肺泡灌洗液中LTB4的濃度比正常組明顯升高(P0.05),COPD+沙丁胺醇組中LTB4的濃度比COPD組明顯降低(P0.05)。肺組織形態(tài)學檢查顯示,COPD組觀察到炎性細胞侵入,肺組織有明顯的炎癥性改變;COPD+沙丁胺醇組可見炎性細胞明顯減少,肺組織炎癥性改變有一定改善。結論支氣管插管單肺通氣中吸入沙丁胺醇能抑制LTB4的濃度。
[Abstract]:Objective to observe the effect of salbutamol on the concentration of leukotriene B _ 4 and LTB _ 4 in serum and alveolar lavage fluid after single lung ventilation in fumigated chronic obstructive pulmonary disease (COPD) rabbits. Methods 18 healthy New Zealand rabbits were divided into normal group and COPD group with 6 in each group. In addition to the normal group, all the other two groups established the COPD experimental rabbit model by the method of self-created by the experimental group. The blood samples were collected before right main bronchus intubation, immediately after intubation, 30 minutes after intubation and 60 minutes after intubation. LTB4 was measured. The rabbits were killed after right main bronchus intubation with single lung ventilation (60min). After dissection, a small amount of upper lobes of lung were taken for histopathological observation, and appropriate amount of bronchoalveolar lavage fluid (BALF) was taken to measure the concentration of LTB4. Results the concentration of LTB4 in bronchoalveolar lavage fluid in COPD group was significantly higher than that in normal group. The concentration of LTB4 in COPD group was significantly lower than that in COPD group. Pulmonary histomorphologic examination showed that inflammatory cell invasion was observed in COPD group, and there were obvious inflammatory changes in lung tissue. In COPD salbutamol group, inflammatory cells were significantly decreased, and inflammatory changes in lung tissue were improved to some extent. Conclusion inhalation of salbutamol can inhibit the concentration of LTB4 during single lung ventilation.
【作者單位】： 河北北方學院附屬第一醫(yī)院麻醉科;河北省張家口市沙嶺子醫(yī)院;河北北方學院第一臨床學院;
【分類號】：R563.9

【相似文獻】

相關期刊論文 前10條

1 秦海慶,趙如明,鄒學超,劉繼;單肺通氣安全時限的臨床研究[J];上海醫(yī)學;2001年12期

2 劉曉江,高光潔,姚靖,張鐵錚,王鳳學;注射用碳酸酰胺過氧化氫在開胸單肺通氣時的應用[J];臨床麻醉學雜志;2004年06期

3 沈寧,陳中剛,甘小亮,馬武華,黑子清;舒氧康在老年患者單肺通氣手術中的應用體會[J];廣東醫(yī)學;2005年08期

4 張晉東;楊曉明;張國榮;任俊清;孫曉東;宋志鴻;范勤;紀軍;;單腔雙囊氣管導管在小兒單肺通氣麻醉中的應用[J];臨床麻醉學雜志;2006年01期

5 黃中華;葉鳳青;李靜;胡彥艷;秦丹丹;張學剛;;低流量單肺通氣對體溫影響的觀察[J];現(xiàn)代醫(yī)藥衛(wèi)生;2013年01期

6 鄭澍;李德龍;廖燕凌;陳彥青;;沐舒坦對單肺通氣患者氧化抗氧化系統(tǒng)相關指標的影響[J];福建醫(yī)藥雜志;2013年04期

7 劉琴湘,鄒冬玲,黃素清;單肺通氣不同時間對血氣影響的探討[J];中國現(xiàn)代醫(yī)學雜志;1998年09期

8 張孟元,姚慧;88例全麻下單肺通氣的處理體會[J];山東醫(yī)藥;1999年20期

9 張秀燕,詹鴻,陳浩文,黃煥娟,陳榮昌;氣管內氣體吹入對單肺通氣效應的影響[J];實用醫(yī)學雜志;2002年08期

10 李偉,王劍,蔣艷波,許梅曦;烏司他丁對術中單肺通氣患者白介素-8的影響[J];癌癥;2003年10期

相關會議論文 前10條

1 任利遠;郭建榮;郭偉;;星狀神經節(jié)阻滯對圍術期單肺通氣缺氧性肺血管收縮的影響[A];2009年浙江省麻醉學學術會議論文匯編[C];2009年

2 陳潔;鐘泰迪;;單肺通氣技術研究進展[A];第八屆華東六省一市胸心血管外科學術會議論文匯編[C];2005年

3 郭偉;郭建榮;;單肺通氣麻醉的研究現(xiàn)狀[A];2008年第七次華東六省一市麻醉學學術會議暨浙江省麻醉學術年會論文匯編（上冊）[C];2008年

4 陶蕾;;長托寧對老年患者單肺通氣所致肺損傷的保護作用[A];全國第三次麻醉藥理學術會議論文集[C];2012年

5 劉勝強;溫小紅;;單肺通氣的研究進展[A];第十二屆華東六省一市麻醉學術會議暨2013年福建省麻醉學術會議論文匯編[C];2013年

6 郭建榮;郭偉;任利遠;金孝\，

本文編號：1868426