本文選題：肺疾病 + 慢性阻塞性��； 參考：《重慶醫(yī)學(xué)》2017年19期

【摘要】：目的探討血清缺血修飾清蛋白(IMA)在慢性阻塞性肺疾病(COPD)病情評(píng)估中的價(jià)值。方法選取2015年9月至2016年3月在該院診治的COPD患者81例納入COPD組(急性加重期50例,穩(wěn)定期31例),同時(shí)收集30例非COPD的志愿者作為對(duì)照組;測(cè)定兩組血清IMA水平并進(jìn)行比較,分析COPD患者血清IMA水平與血清肌紅蛋白(MYO)、肌鈣蛋白T(TNT)、C反應(yīng)蛋白(CRP)水平及全血白細(xì)胞(WBC)計(jì)數(shù)的相關(guān)性,繪制受試者工作特征(ROC)曲線,分析血清IMA水平在COPD的診斷價(jià)值。結(jié)果 COPD組血清IMA水平明顯高于對(duì)照組[84.1(79.1,88.5)U/Lvs.73.1(70.2,75.1)U/L],急性加重期COPD患者血清IMA水平明顯高于穩(wěn)定期患者[85.5(82.3,89.4)U/L vs.78.1(75.9,83.0)U/L],急性加重期和穩(wěn)定期COPD患者血清IMA水平均明顯高于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。COPD患者血清IMA水平與血清MYO水平呈明顯正相關(guān)(r=0.554,P=0.00);ROC曲線表明,當(dāng)取截?cái)嘀禐?6.55U/mL時(shí),IMA診斷COPD的靈敏度為88.5%,特異度為80.0%,ROC曲線下面積為0.88。結(jié)論血清IMA水平在COPD病情評(píng)估方面有較好的臨床價(jià)值,值得擴(kuò)大樣本進(jìn)一步研究。
[Abstract]:Objective to investigate the value of serum ischemia modified albumin (IMA) in the evaluation of chronic obstructive pulmonary disease (COPD). Methods 81 COPD patients treated in our hospital from September 2015 to March 2016 were enrolled in COPD group (acute exacerbation 50 cases, stable 31 cases) and 30 non-COPD volunteers as control group, the serum IMA levels were measured and compared between the two groups. To analyze the correlation between serum IMA level and serum myoglobin (My), troponin C reactive protein (COPD) and WBC count in patients with COPD, to draw the operating characteristics curve of subjects and to analyze the diagnostic value of serum IMA level in COPD. Results the level of serum IMA in COPD group was significantly higher than that in control group [88.5U / L + 88.5U / L], and the serum IMA level in patients with acute exacerbation was significantly higher than that in stable patients [85.5 / 79.1U / L + 88.9U / L], and the level of serum IMA in patients with acute exacerbation and stable COPD was significantly higher than that in the control group (P < 0.05), and the serum IMA level in patients with acute exacerbation and stable COPD was significantly higher than that in patients with acute exacerbation and stable COPD. There was a significant positive correlation between the serum IMA level and the serum MYO level in patients with 76.55U/mL. The results showed that when the truncation value was 76.55U/mL, the sensitivity of COPD was 88. 5%, the specificity was 80. 0% and the area under the ROC curve was 0. 88. Conclusion Serum IMA level has good clinical value in the evaluation of COPD, and it is worthy of further study.
【作者單位】： 重慶醫(yī)科大學(xué)附屬第一醫(yī)院檢驗(yàn)科;
【分類號(hào)】：R563.9

【相似文獻(xiàn)】

相關(guān)會(huì)議論文 前1條

1 鐘定;李慧;丘韶校;李元廣;李莉;;冠心病對(duì)重度COPD病情的影響[A];中華醫(yī)學(xué)會(huì)呼吸病學(xué)年會(huì)——2013第十四次全國(guó)呼吸病學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2013年

，

本文編號(hào)：1830371