本文選題：抑郁癥 + 肺部感染　； 參考：《中華醫(yī)院感染學(xué)雜志》2017年02期

【摘要】：目的探討抑郁癥合并肺部感染患者皮質(zhì)醇、5-羥色胺及炎癥因子變化及相關(guān)性,為臨床診治提供參考。方法選取2014年8月-2015年10月在醫(yī)院診治的抑郁癥患者60例為抑郁癥組,其中并發(fā)肺部感染與單純抑郁癥無(wú)肺部感染患者各30例,同時(shí)選取健康體檢的正常人群60例為對(duì)照(對(duì)照組),對(duì)比各組間血清白細(xì)胞介素-6(IL-6)、腫瘤壞死因子α(TNF-α)、皮質(zhì)醇及5-羥色胺、C-反應(yīng)蛋白(CRP)水平。結(jié)果抑郁組患者CRP、IL-6、TNF-α、皮質(zhì)醇水平高于對(duì)照組,5-羥色胺低于對(duì)照組,比較差異有統(tǒng)計(jì)學(xué)意義(P0.05);抑郁組并發(fā)肺部感染患者CRP、IL-6、TNF-α、皮質(zhì)醇水平分別為(13.84±4.90)mg/L、(16.12±4.02)ng/L、(17.92±2.50)ng/L、(191.14±60.13)μg/L,高于非肺部感染患者(5.82±2.81)mg/L、(5.25±0.30)ng/L、(5.01±1.77)ng/L、(132.04±31.52)μg/L,5-羥色胺為(16.72±5.55)μg/L低于非肺部感染患者(31.84±6.91)μg/L,差異有統(tǒng)計(jì)學(xué)意義(P0.05);中重度抑郁癥患者CRP、IL-6、TNF-α、皮質(zhì)醇水平高于輕度患者,5-羥色胺低于輕度患者,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論抑郁癥患者皮質(zhì)醇及炎癥因子明顯升高,5-羥色胺有所下降,與肺部感染及抑郁嚴(yán)重程度密切相關(guān)。
[Abstract]:Objective to investigate the changes and correlation of cortisol 5-hydroxytryptamine and inflammatory factors in patients with depression complicated with pulmonary infection, and to provide reference for clinical diagnosis and treatment. Methods from August 2014 to October 2015, 60 patients with depression were selected as depression group, including 30 patients with pulmonary infection and 30 patients with simple depression without pulmonary infection. At the same time, 60 healthy people were selected as control group (control group). The serum levels of interleukin-6 (IL-6), tumor necrosis factor 偽 (TNF- 偽), cortisol and serotonin C reactive protein (CRP) were compared. Results the levels of TNF- 偽 and cortisol in the depression group were higher than those in the control group, and the levels of serotonin in the depression group were lower than those in the control group. 姣旇緝宸紓鏈夌粺璁″鎰忎箟(P0.05);鎶戦儊緇勫茍鍙戣偤閮ㄦ劅鏌撴?zhèn)ｈ�匔RP,IL-6,TNF-偽,鐨川閱囨按騫沖垎鍒負(fù)(13.84鹵4.90)mg/L,(16.12鹵4.02)ng/L,(17.92鹵2.50)ng/L,(191.14鹵60.13)渭g/L,楂樹簬闈炶偤閮ㄦ劅鏌撴?zhèn)ｈ�，

本文編號(hào)：1818974