本文選題：肺疾病 + 慢性阻塞性　； 參考：《中國現(xiàn)代醫(yī)學(xué)雜志》2017年21期

【摘要】：目的探討布地奈德聯(lián)合辛伐他汀對慢性阻塞性肺疾病(COPD)大鼠模型炎癥因子與肺組織病理的影響,為藥物干預(yù)方案提供實驗依據(jù)。方法根據(jù)不同的藥物干預(yù)方案將COPD大鼠分為模型組(M組)、布地奈德組(BD組)、辛伐他汀組(SV組)及布地奈德聯(lián)合辛伐他汀組(BD+SV組),比較不同組別COPD大鼠血清和支氣管肺泡灌洗液(BLAF)中的白細(xì)胞介素6(IL-6)、白細(xì)胞介素8(IL-8)、白三烯B4(LTB4)、腫瘤壞死因子α(TNF-α)水平及肺組織病理的改變。結(jié)果血清炎癥因子水平:BD組IL-6、TNF-α,SV組IL-6,(BD+SV)組IL-6、IL-8及TN F-α分別較M組降低(均P0.05);(BD+SV)組IL-8水平較SV組下降(P0.05)。BALF炎癥因子水平:BD組IL-6、IL-8,SV組IL-6、TN F-α,(BD+SV)組IL-6、IL-8、LTB4及TN F-α水平分別較M組降低(均P0.05)。(BD+SV)組BALF中IL-8、LTB4及TNF-α水平較BD組降低,IL-8、LTB4水平較SV組下降(均P0.05)。BD組、SV組、(BD+SV)組肺組織病理半定量評分較M組降低(均P0.05),病理均顯示肺氣腫囊腔變小、支氣管炎癥減輕。結(jié)論使用布地奈德聯(lián)合辛伐他汀可以有效降低COPD大鼠全身和氣道炎癥反應(yīng),改善肺組織病理。
[Abstract]:Objective to investigate the effects of budesonide combined with simvastatin on inflammatory factors and lung histopathology in rats with chronic obstructive pulmonary disease (COPD). Methods according to different drug intervention schemes, COPD rats were divided into three groups: model group (M group), budesonide group (group BD), simvastatin group (group SV) and budesonide combined with simvastatin group (group BD SV). The serum and branches of different groups of COPD rats were compared. The levels of interleukin 6 (IL 6), interleukin 8 (IL 8), leukotriene B 4 (LTB 4) and tumor necrosis factor 偽 (TNF- 偽) in bronchoalveolar lavage fluid (BLAF) and the pathological changes of lung tissue. Results the levels of serum inflammatory cytokines (IL-6TNF- 偽, IL-6TNF- 偽, IL-6TNF- 偽, IL-6TNF- 偽) in group B were lower than those in group M (P 0.05), respectively. The levels of IL-8 in group B were lower than those in group SV (P 0.05), and the levels of IL-6TNF- 偽 in group SV were lower than those in group M (P < 0.05). The levels of IL-6IL-8LTB4 and TN F- 偽 in group SV were significantly lower than those in group M (P < 0.05), and the levels of IL-6TNF- 偽 in group SV were lower than those in group M (P < 0.05). The levels of IL-6TNF- 偽 in group SV were lower than those in group M (P < 0.05). The levels of IL-8, LTB4 and TNF- 偽 in P0.05).(BD group were lower than those in BD group (all P0.05).BD group vs SV group), and the semiquantitative score of lung tissue pathology in P0.05).BD group was lower than that in M group (all P 0.05). Bronchitis is relieved. Conclusion budesonide combined with simvastatin can effectively reduce systemic and airway inflammation and improve lung pathology in COPD rats.
【作者單位】： 四川省醫(yī)學(xué)科學(xué)院.四川省人民醫(yī)院呼吸內(nèi)科;
【基金】：四川省科技廳基礎(chǔ)研究計劃項目(No:2013JY0177)
【分類號】：R563.9

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