本文選題：阻塞性睡眠呼吸暫停低通氣綜合癥 + 體重指數��； 參考：《蚌埠醫(yī)學院》2013年碩士論文

【摘要】：目的： 通過檢測患者血漿神經肽Y的蛋白水平，揭示其與肥胖的關系，及其對OSAHS發(fā)病的影響。 方法： 1、選擇2011年6月至2012年8月在蚌埠醫(yī)學院第一附屬醫(yī)院呼吸內科睡眠治療中心接受多導睡眠圖（PSG）檢測的患者140例，其中男85例，女55例，年齡范圍在50～60歲，平均年齡是53.56±0.71，通過生化檢查及詳細詢問病史排除內分泌代謝性疾病、肝腎功能不全、心血管疾病、腦血管疾病、惡性腫瘤、神經精神系統(tǒng)疾病、風濕性疾病、嚴重的慢性阻塞性肺疾病作為受試對象。 2、根據不同AHI水平將140例入選者分為四組：非0SAHS35人；輕度OSAHS35人；中度OSAHS34人；重度OSAHS36人。 3、按照不同體重指數（BMI）將140例入選者分為五組：正常體重25人；輕度肥胖37人；中度肥胖29人；重度肥胖19人；過重12人。 4、所有入選者均接受一夜至少7小時的PSG監(jiān)測記錄呼吸紊亂指數（AHI）、最低血氧飽和度（LSaO2），同時測量身高（cm）、體重（kg）、腰圍（cm），臀圍（cm），并留取靜脈血進行神經肽Y測定。 結果： 1、不同AHI水平的OSAHS患者，各組間神經肽Y有統(tǒng)計學差異（P＜0.01）；神經肽Y與AHI無直線相關關系，總體相關系數為0.906，呈正相關關系，即OSAHS程度越嚴重神經肽Y水平越高；神經肽Y與LSaO2無直線相關關系，總體相關系數為-0.939，呈負相關關系，，即OSAHS程度越嚴重，LSaO2水平越低，神經肽Y越高。 2、不同BMI水平的的患者，各組間神經肽Y有統(tǒng)計學差異（P0.01）；神經肽Y與BMI無直線相關關系，總體相關系數為0.740，呈正相關關系，即肥胖程度越嚴重，神經肽Y水平越高；通過非參數檢驗，發(fā)現正常體重與肥胖組之間的腰臀比有統(tǒng)計學差異（P＜0.01），神經肽Y與腰臀比的相關系數為0.171，呈正相關關系，即神經肽Y水平隨著腰臀比的增大而增高。 3、神經肽Y與AHI、BMI三者之間的關系可有二重線性回歸方程NPY=5.091+0.437BMI+0.651AHI表示。 結論： OSAHS患者的神經肽Y水平與OSAHS嚴重程度有關，且隨著OSAHS嚴重程度加重而增加；神經肽Y與肥胖、腰臀比有關，且隨著肥胖程度加重、腰臀比增大而增加。
[Abstract]:Objective: The relationship between neuropeptide Y (NPY) and obesity and its effect on the pathogenesis of OSAHS were studied. Methods: 1. From June 2011 to August 2012, 140 patients (85 males and 55 females, aged 50 or 60 years) who were examined by polysomnography (PSG) in the sleep treatment center of Department of Apnea, first affiliated Hospital of Bengbu Medical College, were selected. The average age was 53.56 鹵0.71. Endocrine metabolic diseases, liver and kidney dysfunction, cardiovascular diseases, cerebrovascular diseases, malignant tumors, neuropsychiatric diseases, rheumatic diseases were excluded by biochemical examination and detailed inquiry. Severe chronic obstructive pulmonary disease (COPD) was studied. 2. According to different levels of AHI, 140 patients were divided into four groups: non 0SAHS35, mild OSAHS35, moderate OSAHS34 and severe OSAHS36. 3. According to different body mass index (BMI), 140 patients were divided into five groups: normal weight 25, mild obesity 37, moderate obesity 29, severe obesity 19, overweight 12. 4. All the participants were monitored by PSG for at least 7 hours a night to record the respiratory disorder index (AHI) and the lowest oxygen saturation (LSAO _ 2). At the same time, the body height, body weight, waist circumference, hip circumference and neuropeptide Y were measured at the same time. Results: 1. There was significant difference in neuropeptide Y between OSAHS patients with different AHI levels (P < 0.01), and there was no linear correlation between neuropeptide Y and AHI, the overall correlation coefficient was 0.906, which was positive correlation, that is, the more serious the OSAHS, the higher the neuropeptide Y level. There was no linear correlation between neuropeptide Y and LSaO2, and the overall correlation coefficient was -0.939. There was a negative correlation between neuropeptide Y and neuropeptide Y, that is, the more serious the level of OSAHS, the lower the level of LSaO2, the higher the neuropeptide Y. 2in patients with different levels of BMI, there was significant difference in neuropeptide Y between groups (P 0.01), and there was no linear correlation between neuropeptide Y and BMI, the overall correlation coefficient was 0.740, which was positive correlation, that is, the more severe the obesity, the higher the level of neuropeptide Y; The non-parametric test showed that there were significant differences in the WHR between normal body weight and obesity group (P < 0.01), and the correlation coefficient between neuropeptide Y and WHR was 0.171, which indicated that the level of neuropeptide Y increased with the increase of waist-to-hip ratio. 3. The relationship between neuropeptide Y and AHI 0.437BMI 0.651AHI can be expressed by the double linear regression equation NPY=5.091 0.437BMI 0.651AHI. Conclusion: The level of neuropeptide Y in OSAHS patients was related to the severity of OSAHS and increased with the severity of OSAHS, and neuropeptide Y was related to obesity and waist-hip ratio.
【學位授予單位】：蚌埠醫(yī)學院
【學位級別】：碩士
【學位授予年份】：2013
【分類號】：R563.9

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