發(fā)布時(shí)間：2018-04-11 04:35

  本文選題：慢性阻塞性肺疾病急性加重期 + 細(xì)菌溶解產(chǎn)物�。� 參考：《中國(guó)老年學(xué)雜志》2017年09期

【摘要】：目的探討細(xì)菌溶解產(chǎn)物對(duì)慢性阻塞性肺疾病(COPD)急性加重期(AECOPD)患者免疫功能、臨床療效及肺功能的影響。方法192例AECOPD患者隨機(jī)分為觀察組與對(duì)照組各96例,觀察組在常規(guī)治療的基礎(chǔ)上給予細(xì)菌溶解產(chǎn)物膠囊(泛福舒膠囊)治療。3個(gè)療程結(jié)束后,對(duì)兩組外周血T淋巴細(xì)胞亞群、免疫球蛋白(Ig)、補(bǔ)體、Th17細(xì)胞、Treg細(xì)胞比例進(jìn)行檢測(cè)分析,記錄并比較兩組治療過(guò)程中急性發(fā)作次數(shù)、急性發(fā)作時(shí)間及發(fā)作期間抗生素應(yīng)用時(shí)間;對(duì)比兩組治療后肺功能改善情況。結(jié)果觀察組治療后CD3+細(xì)胞、CD4+細(xì)胞、CD4+/CD8+細(xì)胞比例、免疫球蛋白(Ig)A、Ig G、補(bǔ)體C3、C4水平均高于對(duì)照組,CD8+細(xì)胞低于對(duì)照組(P0.05);觀察組治療后Th17細(xì)胞占CD4+T細(xì)胞比例高于對(duì)照組,Th17/Treg細(xì)胞比例高于對(duì)照組(P0.05)。觀察組治療后急性發(fā)作次數(shù)、急性發(fā)作時(shí)間及抗生素應(yīng)用時(shí)間均少于對(duì)照組(P0.05)。觀察組治療12、24 w中發(fā)作及反復(fù)發(fā)作者比例低于對(duì)照組(P0.05)。觀察組治療后肺功能改變情況優(yōu)于對(duì)照組(P0.05)。結(jié)論細(xì)菌溶解產(chǎn)物能提高AECOPD患者的體液免疫及細(xì)胞免疫功能,增強(qiáng)機(jī)體的抗感染能力,降低COPD急性發(fā)作及反復(fù)發(fā)作次數(shù),改善COPD患者的肺功能狀態(tài)。
[Abstract]:Objective to investigate the effects of bacterial lysates on immune function, clinical efficacy and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease (cad).Methods 192 patients with AECOPD were randomly divided into two groups: the observation group (n = 96) and the control group (n = 96).The ratio of Th17 cells to Treg cells was detected and analyzed, and the times of acute attack, the time of acute attack and the time of antibiotic application during the treatment were recorded and compared between the two groups, and the improvement of lung function was compared between the two groups.Results the percentage of CD4 / CD8 cells in CD3 cells after treatment was observed.The levels of Ig G and C 3 C 3 C 4 in immunoglobulin G were higher than those in the control group, and the percentage of Th17 cells in CD4 T cells was higher than that in the control group after treatment (P 0. 05%, P 0. 05%, P 0 05, P 0 05, P 0 05, P 0 05, P 0 05, P 0 05, P 0 05, P 0 05, P 0 05, P 0 05).The times of acute attack, the time of acute attack and the time of antibiotic application in the observation group were less than those in the control group (P 0.05).The rate of attack and recurrent attack in the observation group was lower than that in the control group (P 0.05).The change of pulmonary function in the observation group was better than that in the control group after treatment (P 0.05).Conclusion bacterial lysates can improve the humoral and cellular immune function of patients with AECOPD, enhance the ability of anti-infection, reduce the number of acute and recurrent attacks of COPD, and improve the pulmonary function of COPD patients.
【作者單位】： 東莞市第五人民醫(yī)院呼吸內(nèi)科;
【基金】：東莞市科技計(jì)劃(No.2015105101091)
【分類(lèi)號(hào)】：R563.9

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