發(fā)布時間：2018-04-10 02:17

  本文選題：益氣活血化痰方　切入點：阿托伐他汀　出處：《重慶醫(yī)學》2017年28期

【摘要】：目的探討益氣活血化痰方聯(lián)合小劑量阿托伐他汀對高危性慢性阻塞性肺疾病(COPD)患者動脈僵硬度、血液黏度及預后的影響。方法隨機數(shù)字表法將240例存在心血管病變危險因素的高危性COPD患者分成他汀組(A組)、益氣活血化痰組(B組)、聯(lián)合組(C組)和對照組(D組),每組60例。4組均予以常規(guī)治療方案,A組聯(lián)合小劑量阿托伐他汀,B組聯(lián)合益氣活血化痰方,C組在A組基礎上聯(lián)合益氣活血化痰方,均持續(xù)治療6個月。觀察4組治療前后中醫(yī)證候積分、動脈僵硬度指標及血液流變學指標變化差異,記錄其不良反應發(fā)生情況及預后情況。結果治療6個月后,4組患者中醫(yī)證候積分及頸動脈-股動脈脈搏波傳導速度(PWV)水平均較治療前明顯降低,且C組、A組、B組、D組逐漸升高(P0.05)。治療6個月后,除D組患者全血黏度、紅細胞壓積未見明顯改變(P0.05),其余3組患者均較治療前明顯降低,C組明顯低于A組和B組(P0.05),A組和B組比較差異無統(tǒng)計學意義(P0.05)。4組患者不良反應發(fā)生率比較差異無統(tǒng)計學意義(P0.05),C組、A組、B組、D組患者BODE指數(shù)逐漸升高(P0.05)。結論益氣活血化痰方聯(lián)合小劑量阿托伐他汀對調(diào)節(jié)有心血管病變危險因素的高危性COPD患者血液流變學狀態(tài)、促進患者預后恢復等具有積極作用。
[Abstract]:Objective to investigate the Yiqi Huoxue Huatan Decoction Combined with small dose of atorvastatin on high risk of chronic obstructive pulmonary disease (COPD) patients with arterial stiffness, affecting blood viscosity and prognosis. Methods randomly 240 cases of cardiovascular disease and risk factors of high-risk COPD patients were divided into atorvastatin group (A group), Guanxinping group (B group), combination group (C group) and control group (D group), each group of 60 cases of.4 group were given conventional treatment, A group combined with low-dose atorvastatin, B group combined with Yiqi Huoxue Huatan recipe group, C in A were based on the combination of vital qi blood phlegm, continued 6 months of treatment. The 4 groups were observed before and after treatment of TCM syndrome integral, index difference of arterial stiffness index and blood rheology, record the occurrence of adverse reactions and prognosis. Results 6 months after treatment, 4 groups of patients with TCM syndrome score and carotid femoral pulse wave conduction Speed (PWV) levels were significantly lower than that before treatment, and C group, A group, B group, D group increased (P0.05). After 6 months of treatment, patients in D group blood viscosity, hematocrit did not change significantly (P0.05), the other 3 groups of patients were significantly lower than that before treatment, C group was significantly lower than that of A group and B group (P0.05), there was no significant difference between A group and B group (P0.05).4 groups of patients with adverse reaction rate had no significant difference (P0.05), C group, A group, B group, BODE index in patients with D group increased (P0.05). Conclusion Yiqi Huoxue Huatan recipe combined with small dose of atorvastatin with cardiovascular disease risk factors on the regulation of high-risk COPD patients blood rheology, promote the prognosis of recovery has a positive effect.

【作者單位】： 新疆醫(yī)科大學第一附屬醫(yī)院中醫(yī)內(nèi)科;
【分類號】：R563.9

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本文編號：1729217