發(fā)布時(shí)間：2018-04-03 12:57

  本文選題：骨質(zhì)疏松　切入點(diǎn)：慢性阻塞性肺疾病　出處：《新鄉(xiāng)醫(yī)學(xué)院》2017年碩士論文

【摘要】：背景慢性阻塞性肺疾病是一種慢性炎癥性肺疾病,易并發(fā)包括骨質(zhì)疏松在內(nèi)的多種并發(fā)癥,并發(fā)癥顯著增加致殘率,死亡率和加重慢性阻塞性肺疾病的經(jīng)濟(jì)負(fù)擔(dān)。其并發(fā)的骨質(zhì)疏松及骨折導(dǎo)致病情惡化,甚至死亡。至今有關(guān)慢性阻塞性肺疾病繼發(fā)性骨質(zhì)疏松癥肯定的危險(xiǎn)因素有:吸煙,缺氧,全身炎癥反應(yīng),糖皮質(zhì)激素的使用,營養(yǎng)缺乏和高甲狀旁腺激素。有學(xué)者研究發(fā)現(xiàn)不同民族及地域人群部分疾病的患病率發(fā)病危險(xiǎn)因素存在民族及地域差異。新疆地區(qū)慢性阻塞性肺疾病繼發(fā)性骨質(zhì)疏松的發(fā)病危險(xiǎn)因素在維吾爾族和漢族間是否存在差異,亟待研究。目的探索慢性阻塞性肺疾病繼發(fā)性骨質(zhì)疏松癥的危險(xiǎn)因素在維吾爾族男性和漢族男性之間的差異,為新疆慢性阻塞性肺疾病繼發(fā)性骨質(zhì)疏松癥的預(yù)防和控制提供參考。方法選取新疆哈密地區(qū)中心醫(yī)院、哈密紅星醫(yī)院呼吸內(nèi)科2015年10月至2016年12月住院患者,經(jīng)詢問病史、體格檢查及肺功能檢查明確診斷為慢性阻塞性肺疾病,且經(jīng)骨頭密度測定儀明確診斷合并骨質(zhì)疏松的男性患者,共收集107例男性患者,按民族分兩組,一組為維吾爾族56例,另一組為漢族51例,兩組患者均檢測缺氧指標(biāo)氧分壓、全身炎癥指標(biāo)C反應(yīng)蛋白、甲狀旁腺激素水平,稱體重及量身高計(jì)算體重指數(shù),調(diào)查吸煙情況并計(jì)算吸煙量,調(diào)查年齡及有無使用全身糖皮質(zhì)激素病史,分別比較兩組患者的年齡、氧分壓、C反應(yīng)蛋白、甲狀旁腺激素、體重指數(shù)、吸煙量及使用全身糖皮質(zhì)激素史。結(jié)果維吾爾族組:年齡為(68.95±6.56)歲,氧分壓為(57.89±6.38)mmHg,C反應(yīng)蛋白為(52.40±59.50)mg/l,甲狀旁腺激素為(55.98±35.92)pg/ml,體重指數(shù)為(19.21±2.71)kg/m2,吸煙量為(20.73±17.92)包/年;漢族組:年齡為(68.12±7.12)歲,氧分壓為(59.21±6.23)mmHg,C反應(yīng)蛋白為(56.57±51.04)mg/l,甲狀旁腺激素水平(39.52±30.31)pg/ml,體重指數(shù)為(21.98±3.96)kg/m2,吸煙量為(15.47±14.72)包/年。年齡兩組P0.05無統(tǒng)計(jì)學(xué)差異;甲狀旁腺激素、體重指數(shù)兩個(gè)危險(xiǎn)因素P0.05,具有統(tǒng)計(jì)學(xué)差異;氧分壓、C反應(yīng)蛋白和吸煙量三個(gè)危險(xiǎn)因素P0.05無統(tǒng)計(jì)學(xué)差異;糖皮質(zhì)激素使用史,維吾爾族組27例(56例),漢族組28例(51例),χ2值0.29,P0.05無統(tǒng)計(jì)學(xué)差異。結(jié)論新疆地區(qū)慢性阻塞性肺疾病繼發(fā)性骨質(zhì)疏松的發(fā)病危險(xiǎn)因素在維吾爾族男性和漢族男性間存在差異;低體重指數(shù)和高甲狀旁腺激素水平在慢性阻塞性肺疾病繼發(fā)性骨質(zhì)疏松中起的作用維吾爾族組大于漢族組。
[Abstract]:Background chronic obstructive pulmonary disease (COPD) is a chronic inflammatory pulmonary disease, which is prone to complications, including osteoporosis, which can significantly increase the rate of disability, mortality and the economic burden of chronic obstructive pulmonary disease (COPD).Its concomitant osteoporosis and fracture cause the condition to worsen, even die.The risk factors associated with COPD secondary osteoporosis are smoking, hypoxia, systemic inflammation, glucocorticoid use, nutritional deficiency and hyperparathyroid hormone.Some scholars have found that there are ethnic and regional differences in the prevalence risk factors of some diseases among different nationalities and regions.The risk factors of secondary osteoporosis of chronic obstructive pulmonary disease (COPD) in Xinjiang area are different between Uygur and Han nationality, which need to be studied urgently.Objective to explore the difference of risk factors of secondary osteoporosis of chronic obstructive pulmonary disease (COPD) between Uygur and Han males, and to provide a reference for the prevention and control of secondary osteoporosis of chronic obstructive pulmonary disease (COPD) in Xinjiang.Methods selected inpatients from October 2015 to December 2016, Department of Respiratory Medicine, Hami Hongxing Hospital, Xinjiang Hami District Central Hospital. The patients were diagnosed as chronic obstructive pulmonary disease by asking for medical history, physical examination and pulmonary function examination.A total of 107 male patients were divided into two groups according to their nationalities: 56 Uygur patients and 51 Han nationality patients. The oxygen partial pressure (oxygen partial pressure) was measured in both groups.Total body inflammation index C-reactive protein, parathyroid hormone level, weight and body height, body mass index, smoking status and smoking volume, age and history of use of systemic glucocorticoid were investigated.Age, oxygen pressure C-reactive protein, parathyroid hormone, body mass index, smoking volume and history of use of glucocorticoid were compared between the two groups.緇撴灉緇村惥灝?dāng)鏃従l，

本文編號：1705289