本文選題：高脂血癥　切入點(diǎn)：動(dòng)脈粥樣硬化　出處：《福建醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的：探討高脂血癥對(duì)肺功能二者之間的關(guān)聯(lián)。 方法：選取海島及周邊地區(qū)健康成人其中30～70歲年齡組2030例（其中男736例，女1294例，平均年齡50.74±10.35歲。），對(duì)受檢者進(jìn)行體格檢查、血生化檢查（包括TC、TG、HDL、LDLC、GLU）及肺通氣功能檢查（FVC%、FEV1%、FEV1/FVC），采用SPSS17.0軟件進(jìn)行統(tǒng)計(jì)學(xué)處理，因素間相關(guān)性探討采用直線相關(guān)分析、多元逐步回歸分析。 結(jié)果：對(duì)肺通氣功能（FVC%、FEV1%、FEV1/FVC）與不同血脂成分進(jìn)行直線相關(guān)分析，結(jié)果表明，F(xiàn)VC%（r＝－0.050，P＝0.025）、FEV1%（r＝－0.068，P＝0.002）、FEV1/FVC（r＝－0.077，P＝0.000）均分別與lgTG之間存在負(fù)的直線相關(guān)關(guān)系；FVC%（r＝－0.009，P＝0.679）、FEV1%（r＝0.025，P＝0.256）、FEV1/FVC （r＝－0.026，P＝0.237）與TC之間不存在直線相關(guān)關(guān)系；FVC%（r＝0.035，P＝0.118）、FEV1%（r＝0.031，P＝0.166）、FEV1/FVC（r＝0.018，，P＝0.409）與HDL之間不存在直線相關(guān)關(guān)系；FVC%（r＝－0.005，P＝0.828）、FEV1%（r＝0.038，P＝0.090）、FEV1/FVC（r＝0.038，P＝0.373）與LDLC之間不存在直線相關(guān)關(guān)系。進(jìn)一步分別以FVC%、FEV1%、FEV1/FVC為應(yīng)變量，以年齡、收縮壓、舒張壓、BMI、GLU、lgTG、TC、HDL、LDLC為自變量進(jìn)行多元逐步回歸分析，結(jié)果表明，F(xiàn)VC%（β＝－2.623，P＝0.043）、FEV1%（β＝－5.323，P＝0.000）、FEV1/FVC（β＝－1.272，P＝0.022）的變化均與lgTG有線性回歸關(guān)系，且與lgTG呈負(fù)相關(guān)。 結(jié)論：lgTG分別與FVC%、FEV1%、FEV1/FVC存在負(fù)的直線相關(guān)關(guān)系，多元回歸分析表明，F(xiàn)VC%、FEV1%、FEV1/FVC與lgTG負(fù)相關(guān)，提示肺通氣功能與甘油三酯負(fù)相關(guān)。肺通氣功能（FVC%、FEV1%、FEV1/FVC）與血清總膽固醇、高密度脂蛋白、低密度脂蛋白膽固醇之間無直線相關(guān)關(guān)系。
[Abstract]:Objective: to investigate the relationship between hyperlipidemia and pulmonary function. Methods: 2030 healthy adults (male 736, female 1294, mean age 50.74 鹵10.35 years) were selected from 30 to 70 year old adults in the island and surrounding areas. Blood biochemical examination (including TCU TGG / HDLLDLCU) and pulmonary ventilation function test (FVCU) were performed with SPSS17.0 software. Linear correlation analysis and multiple stepwise regression analysis were used to analyze the correlation among the factors. Results: a linear correlation analysis was made between FEV1 / FVC) and different blood lipid components. The results showed that there was a negative linear correlation between FEV1 / FVCr-0.077P0.000 and FEV1 / FVCr-0.077P0.000, respectively. There was no relationship between FEVC1FVC r-0.026P0.237) and FEVC1r-0.009P0.679P0.000. there was no relationship between FEVC1FVC r-0.026P0.237) and TC. Don't take FVC1 as the dependent variable for FEV1 / FVC. Multivariate stepwise regression analysis was carried out with age, systolic blood pressure, diastolic blood pressure (BMI-5.323P0.000FEV1 / FVC-1 (尾 -1.272P0. 022) and negative correlation with lgTG). The results showed that there was a linear regression relationship between lgTG and FVC (尾 -2.623 P0. 043) and a negative correlation between FV1 / FVC (尾 -1.272 P0. 022) and FEV1 (尾 -5.323P0. 000FVC (尾 -1.272) P0. 022). Conclusion there was a negative linear correlation between FVC and FEV1 / FVC. Multiple regression analysis showed that FEV1 / FVC was negatively correlated with lgTG, suggesting that pulmonary ventilation function was negatively correlated with triglyceride. There was no linear correlation between low density lipoprotein cholesterol.
【學(xué)位授予單位】：福建醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R589.2;R563

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相關(guān)期刊論文 前10條

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本文編號(hào)：1685277