發(fā)布時(shí)間：2018-03-24 14:36

  本文選題：肺功能　切入點(diǎn)：彌散功能　出處：《中國(guó)實(shí)用內(nèi)科雜志》2014年S1期

【摘要】：目的探討一次性呼吸過(guò)濾器對(duì)一口氣呼吸法肺一氧化碳彌散功能檢查結(jié)果的影響。方法采用自身隨機(jī)交叉對(duì)照試驗(yàn),對(duì)16名受試者進(jìn)行一口氣彌散功能測(cè)定,比較應(yīng)用與不應(yīng)用一次性呼吸過(guò)濾器(Microgard,美國(guó)Carefusion公司)測(cè)定一口氣彌散功能的差異。測(cè)試過(guò)程及質(zhì)量控制按照ATS/ERS的一口氣呼吸法肺一氧化碳彌散功能測(cè)定標(biāo)準(zhǔn)進(jìn)行。主要觀察指標(biāo)為肺一氧化碳彌散量(DLCO),取兩次或兩次以上可接受測(cè)試的均值記錄,測(cè)定數(shù)值以均數(shù)±標(biāo)準(zhǔn)差來(lái)表示,組間比較采用配對(duì)t檢驗(yàn),P0.05為統(tǒng)計(jì)學(xué)有差異。結(jié)果 16例受試者完成試驗(yàn)。其中男11例,女5例,年齡21~80歲,平均(21.50±18.17)歲。一口氣彌散功能指標(biāo)DLCO的基線值為(5.83±2.03)mol/(min·kPa),應(yīng)用一次性呼吸過(guò)濾器后,DLCO為(5.92±1.93)mol/(min·kPa),應(yīng)用過(guò)濾器后DLCO值的平均差異分別為(0.30±0.34)mol/(min·kPa)(P=0.117),組間差異無(wú)統(tǒng)計(jì)學(xué)意義。16例受試者應(yīng)用過(guò)濾器前后肺彌散功能結(jié)果診斷的一致率為100%。結(jié)論盡管應(yīng)用Microgard呼吸過(guò)濾器后,DLCO值有所改變,但其差異不具有統(tǒng)計(jì)學(xué)意義,且其差異在彌散功能指標(biāo)的個(gè)體重復(fù)性變化范圍以內(nèi),并不會(huì)對(duì)受試者的肺功能臨床診斷與評(píng)級(jí)造成明顯的影響,故這種差異無(wú)重要的臨床意義�？傊�,過(guò)濾器不影響彌散功能測(cè)定結(jié)果,適于在臨床上應(yīng)用。
[Abstract]:Objective to investigate the effect of one-off breathing filter on the results of pulmonary carbon monoxide dispersion function by one-breath breathing method. To compare the difference between using and not using one-time breath filter Microgard (Carefusion Company, USA) to determine the function of one-breath dispersion. The testing process and quality control were carried out according to the standard of ATS/ERS 's one-breath breathing method for determining the carbon monoxide dispersion function of the lung. The main outcome measures were lung carbon monoxide dispersion volume (DLCOG), and the mean values of two or more acceptable tests were recorded. The measured values were expressed as mean 鹵standard deviation. There was statistical difference between the two groups by pairing t test (P0.05). Results Sixteen subjects completed the test, including 11 males and 5 females, aged 2180 years. The average value of DLCO was 21.50 鹵18.17 years old. The baseline value of DLCO was 5.83 鹵2.03)mol/(min KPA, and that of DLCO was 5.92 鹵1.93)mol/(min KPA after one breath filter. The average difference of DLCO value after the application of filter was 0.30 鹵0.34)mol/(min KPA 0.117. There was no significant difference between the two groups. The consistent rate of diagnosis of pulmonary diffusivity before and after filter was 100. Conclusion although the Microgard respiratory filter was used, there was a change in DLCO value. However, the difference was not statistically significant, and the difference was within the range of individual reproducibility of the diffusive function index, which did not have a significant effect on the clinical diagnosis and rating of pulmonary function. Therefore, this difference has no important clinical significance. In a word, filter does not affect the results of dispersion function measurement and is suitable for clinical application.
【作者單位】： 廣州醫(yī)科大學(xué);廣州醫(yī)科大學(xué)附屬第一醫(yī)院廣州呼吸疾病研究所(呼吸疾病國(guó)家重點(diǎn)實(shí)驗(yàn)室呼吸疾病國(guó)家臨床研究中心);
【分類號(hào)】：R563

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本文編號(hào)：1658727