本文選題：維生素C　切入點：阿司匹林　出處：《中國醫(yī)院藥學雜志》2014年12期 　論文類型：期刊論文

【摘要】：目的:建立吸煙致小鼠肺損傷模型,研究維生素C(VC)和阿司匹林(ASP)聯(lián)合用藥對吸煙致肺損傷的干預作用。方法:將A/J小鼠隨機分成5組:正常組、模型組、維生素C組、阿司匹林組、阿司匹林聯(lián)合維生素C組,并取肺組織進行相關(guān)生化指標檢測及組織病理觀察。結(jié)果:模型組與正常組比較,肺組織中的超氧化物歧化酶(SOD)活性和谷胱甘肽(GSH)含量明顯降低,丙二醛(MDA)含量則明顯升高,同時肺組織病理觀察發(fā)現(xiàn)有明顯的炎癥細胞浸潤和明顯的肺纖維化表現(xiàn)。維生素C組、阿司匹林組以及維生素C聯(lián)合阿司匹林組與模型組比較,肺組織的SOD活性和GSH含量升高,MDA含量降低,但僅維生素C聯(lián)合阿司匹林組的數(shù)據(jù)有統(tǒng)計學意義,且組織病理觀察結(jié)果顯示該組小鼠肺泡結(jié)構(gòu)完整,炎癥癥狀更輕,羥脯氨酸(HYP)含量也明顯低于模型組。結(jié)論:吸煙能夠?qū)е滦∈蠓螕p傷,VC和ASP對吸煙所致的肺損傷有預防作用,且VC和ASP聯(lián)合用藥比單一用藥預防效果更佳。
[Abstract]:Objective: to establish a model of lung injury induced by smoking in mice, and to study the intervention effect of vitamin C (VC) and aspirin (ASP) on lung injury induced by smoking. Methods: A- / J mice were randomly divided into 5 groups: normal group, model group, vitamin C group. Aspirin group, aspirin combined with vitamin C group, and lung tissues were taken for the detection of biochemical indicators and histopathological observation. Results: the model group compared with the normal group, The activity of superoxide dismutase (SOD) and the content of glutathione (GSH) in lung tissue decreased significantly, while the content of malondialdehyde (MDA) increased significantly. At the same time, the pathological observation of lung tissue showed obvious inflammatory cell infiltration and obvious pulmonary fibrosis. Compared with the model group, the vitamin C group, aspirin group and vitamin C combined aspirin group, The activity of SOD and the content of GSH in lung tissue increased and decreased, but only the data of vitamin C combined with aspirin group were statistically significant. The histopathological results showed that the alveolar structure of the group was intact and the inflammatory symptoms were more mild. Conclusion: smoking can induce lung injury induced by VC and ASP in mice, and the combination of VC and ASP can prevent lung injury.
【作者單位】： 廣東醫(yī)學院藥學院藥理學教研室;
【基金】：國家自然科學(面上項目)基金資助(編號:81273518) 廣東省科技計劃項目(編號:2010B06050)
【分類號】：R563.8

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