本文選題：孟魯司特　切入點(diǎn)：老年人　出處：《臨床耳鼻咽喉頭頸外科雜志》2017年20期 　論文類型：期刊論文

【摘要】：目的:研究孟魯司特對(duì)老年支氣管哮喘合并OSAHS患者呼出氣一氧化氮(FeNO)及炎癥因子的影響。方法:選取老年支氣管哮喘患者150例,篩選經(jīng)多導(dǎo)睡眠圖監(jiān)測(cè)確診合并OSAHS的患者,分為哮喘合并OSAHS組(n=72)和單純哮喘組(n=78),兩組按照治療方法不同再分為觀察組和對(duì)照組。兩組均給予止咳、化痰、吸入激素平喘等常規(guī)治療,觀察組同時(shí)加用孟魯司特10mg,每晚1次口服。治療前及治療1個(gè)月后分別行一氧化氮呼出氣檢測(cè),采血取上清液檢測(cè)腫瘤壞死因子α(TNR-α)、C反應(yīng)蛋白(CRP)和IL-6,根據(jù)睡眠監(jiān)測(cè)結(jié)果計(jì)算AHI,對(duì)比分析兩組患者FeNO水平、CRP、TNR-α、IL-6、AHI的變化情況。結(jié)果:治療前,兩組患者性別、年齡、病情程度、FeNO水平、TNR-α、CRP、IL-6、AHI差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療后兩組FeNO水平、TNR-α、CRP、IL-6、AHI較治療前均下降(P0.05),且觀察組均低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(炎癥因子P0.05,AHI、FeNO水平P0.01)。結(jié)論:孟魯司特可降低老年支氣管哮喘合并OSAHS患者的TNR-α、CRP、IL-6、AHI和FeNO水平,可為老年支氣管哮喘合并OSAHS患者的臨床用藥提供參考。
[Abstract]:Objective: to study the effects of montelukast on exhalation nitric oxide (no) and inflammatory factors in elderly patients with bronchial asthma complicated with OSAHS. Methods: 150 elderly patients with bronchial asthma were selected and the patients with OSAHS diagnosed by polysomnography were selected. The two groups were divided into two groups according to different treatment methods: observation group and control group. Both groups were given routine treatment such as cough relief, phlegm reduction and inhaling hormone to relieve asthma. In the observation group, 10 mg of montelukast was administered at the same time, once a night. The exhalation of nitric oxide was detected before treatment and 1 month after treatment. Serum samples were collected to detect the levels of tumor necrosis factor 偽 -TNR- 偽 titran C-reactive protein (CRP) and interleukin-6 (IL-6). According to the results of sleep monitoring, the changes of FeNO level and TNR- 偽 TNF- 偽 IL-6AHI were compared between the two groups. Results: before treatment, the sex and age of the patients in the two groups were analyzed. There was no significant difference in the level of FeNO between the two groups (P 0.05). After treatment, the level of FeNO in the two groups was lower than that in the control group (P 0.05), and it was lower in the observation group than that in the control group. Conclusion: montelukast can reduce the levels of TNR- 偽 CRPIL-6 AHI and FeNO in elderly patients with bronchial asthma and OSAHS, and can provide reference for clinical use of OSAHS in elderly patients with asthma.
【作者單位】： 華北理工大學(xué)附屬醫(yī)院呼吸科;
【基金】：河北省高等學(xué)�？茖W(xué)技術(shù)研究項(xiàng)目(No:ON2016198) 2015年度河北省醫(yī)學(xué)科學(xué)研究重點(diǎn)課題計(jì)劃(No:20150535) 2017年度河北省醫(yī)學(xué)科學(xué)研究重點(diǎn)課題計(jì)劃(No:20170914)
【分類號(hào)】：R562.25;R766

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