本文選題：慢性阻塞性肺疾病　切入點：真菌感染　出處：《中華醫(yī)院感染學(xué)雜志》2014年17期 　論文類型：期刊論文

【摘要】：目的探討慢性阻塞性肺疾病(COPD)患者急性加重期繼發(fā)肺部真菌感染菌群分布及相關(guān)危險因素,為感染預(yù)防提供參考依據(jù)。方法對2011年1月-2013年3月收治的314例COPD急性加重期患者繼發(fā)肺部真菌感染進行回顧性分析,分析患者的菌群分布及感染危險因素。結(jié)果 314例患者發(fā)生肺部真菌感染76例,感染率為24.2%;檢出白色假絲酵母菌46株占60.5%、光滑假絲酵母菌8株占10.5%、熱帶假絲酵母菌8株占10.5%、酵母樣真菌6株占7.9%、克柔假絲酵母菌3株占3.9%、曲霉菌屬5株占6.6%;經(jīng)單因素logistic回歸分析合并糖尿病、機械通氣、血清白蛋白35g/L,Ⅱ型呼吸衰竭、長期使用糖皮質(zhì)激素、長期應(yīng)用廣譜抗菌藥物6個變量與繼發(fā)真菌感染相關(guān)(P0.05);經(jīng)多因素logistic回歸分析,合并糖尿病、機械通氣、長期使用糖皮質(zhì)激素、長期應(yīng)用廣譜抗菌藥物是COPD急性加重期繼發(fā)肺部真菌感染的獨立危險因素(P0.05)。結(jié)論 COPD急性加重期肺部真菌感染發(fā)病率較高,應(yīng)采取預(yù)防控制措施,以降低感染率。
[Abstract]:Objective to investigate the distribution and risk factors of secondary pulmonary fungal infection in patients with chronic obstructive pulmonary disease (COPD) during acute exacerbation. Methods from January 2011 to March 2013, 314 cases of pulmonary fungal infection secondary to acute exacerbation of COPD were retrospectively analyzed. The distribution of bacteria and the risk factors of infection were analyzed. Results there were 76 cases of pulmonary fungal infection in 314 cases. The infection rate was 24.2%, 46 strains of Candida albicans accounted for 60.5%, 8 strains of Candida smooth cells accounted for 10.5%, 8 strains of Candida tropicalis strains accounted for 10.5%, 6 strains of yeast-like fungi accounted for 7.9%, 3 strains of Candida cerevisiae accounted for 3.9 strains, and 5 strains of Aspergillus accounted for 6.6B. Factor logistic regression analysis with diabetes mellitus, Mechanical ventilation, serum albumin 35g / L, type 鈪，

本文編號：1558722