發(fā)布時間：2018-02-28 23:34

  本文關(guān)鍵詞： 利奈唑胺 糞腸球菌 臨床耐藥 定植 同源性　出處：《中國感染控制雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的研究1例患者體內(nèi)利奈唑胺(LZD)耐藥糞腸球菌臨床分離株與定植株同源性特點。方法對1例肺部感染患者分離的10株糞腸球菌(其中2株分離自尿標(biāo)本,8株分離自糞便標(biāo)本)進行細菌耐藥分析,并通過脈沖場凝膠電泳(PFGE)確定糞腸球菌之間的同源性。結(jié)果患者進行LZD治療前后,尿標(biāo)本分離出的2株糞腸球菌均為LZD耐藥株(MIC值分別為8 mg/mL,16 mg/mL),糞便中培養(yǎng)挑取的8株(治療前6株,治療后2株),其中LZD敏感4株,中介2株,耐藥2株(MIC值波動在0.25~12 mg/mL)。通過PFGE分型檢測提示10株糞腸球菌具有同源性。結(jié)論該例患者泌尿道和腸道檢出的糞腸球菌具有同源性,提示LZD耐藥腸球菌可能長期定植于患者體內(nèi),并可能發(fā)生移位導(dǎo)致耐藥細菌感染。
[Abstract]:Objective to study the homology of clinical isolates of drug-resistant Enterococcus faecalis from a patient with LZD. Methods 10 strains of Enterococcus faecalis isolated from a patient with pulmonary infection were isolated from 10 strains of Enterococcus faecalis (including 2 strains isolated from urine). Analysis of bacterial drug resistance, The homology of Enterococcus faecalis was determined by pulsed field gel electrophoresis (PFGE). Results the patients were treated with LZD before and after treatment. The LZD values of two strains of Enterococcus faecalis isolated from urine samples were 8 mg / m L ~ (-1) and 16 mg / m ~ (-1), respectively, and 8 strains (6 strains before treatment and 2 strains after treatment) were isolated from feces, among which 4 strains were sensitive to LZD and 2 strains were mediators. The results showed that 10 strains of Enterococcus faecalis had homology by PFGE typing. Conclusion the detection of Enterococcus faecalis in urinary tract and intestinal tract in this case has homology, suggesting that LZD resistant Enterococcus may be colonized in the patient for a long time. Translocation may lead to resistant bacterial infection.
【作者單位】： 廣東醫(yī)科大學(xué)附屬深圳市南山區(qū)人民醫(yī)院深圳市內(nèi)源性感染診治研究重點實驗室;
【基金】：深圳市科技創(chuàng)新委基礎(chǔ)研究基金項目(JCYJ20150402152130173) 深圳市南山區(qū)科技項目(2015019,2015022)
【分類號】：R563.1
，

本文編號：1549488