本文關(guān)鍵詞： 個體化腸內(nèi)營養(yǎng) 呼吸康復(fù) 肺功能 CAT 淋巴細(xì)胞絕對值　出處：《山西醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:慢阻肺是一種氣流受限不完全可逆的,呈進(jìn)行性發(fā)展的肺部疾病,延緩此類患者肺功能的進(jìn)展至關(guān)重要,藥物治療有一定的局限性,在此基礎(chǔ)上新的治療方案有待研究。本研究通過觀察常規(guī)治療基礎(chǔ)上的個體化腸內(nèi)營養(yǎng)結(jié)合呼吸康復(fù)治療對急性加重期慢阻肺(AECOPD)患者肺功能、營養(yǎng)狀況、免疫功能、生活狀況的改善,評價其對AECOPD的治療意義及價值,為AECOPD的臨床治療增添新的思路。方法:本研究為臨床隨機(jī)對照研究。收集山西省汾陽醫(yī)院2015-10至2016-5期間80例AECOPD的患者,隨機(jī)分組(兩組各40例)。實(shí)驗(yàn)組行呼吸康復(fù)治療+個體化腸內(nèi)營養(yǎng)+常規(guī)治療,對照組行常規(guī)對癥支持治療+常規(guī)飲食治療。兩組患者均治療14天。治療前后對患者進(jìn)行慢阻肺生活評分量表(CAT)評分,并測定肺功能、淋巴細(xì)胞數(shù)及營養(yǎng)狀況相關(guān)指標(biāo)。對結(jié)果進(jìn)行統(tǒng)計(jì)分析并得出結(jié)論。結(jié)果:(1)兩組患者治療前肺功能(FEV1、FVC)、血清前白蛋白、血清白蛋白、CAT、淋巴細(xì)胞比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。(2)兩組患者治療后FEV1、血清前白蛋白、血清白蛋白均得到改善,差別具有統(tǒng)計(jì)學(xué)意義(P0.01),實(shí)驗(yàn)組治療后效果較對照組顯著(P0.01)。(3)兩組患者治療后FVC得到改善,差別具有統(tǒng)計(jì)學(xué)意義(P0.01),實(shí)驗(yàn)組治療后效果較對照組無明顯差異(P=0.94)。(4)實(shí)驗(yàn)組患者治療后CAT、淋巴細(xì)胞得到改善,差別具有統(tǒng)計(jì)學(xué)意義(P0.01),對照組患者治療前后無明顯差別(P0.05)。結(jié)論:與常規(guī)治療相比,聯(lián)合個體化腸內(nèi)營養(yǎng)和呼吸康復(fù)治療方案可有效改善肺功能、免疫功能及營養(yǎng)狀態(tài),提高患者生活質(zhì)量。
[Abstract]:Objective: chronic obstructive pulmonary disease (COPD) is a kind of pulmonary disease which is not completely reversible with airflow limitation. It is very important to delay the progress of pulmonary function in these patients. In this study, the effects of individual enteral nutrition combined with respiratory rehabilitation on pulmonary function, nutritional status and immune function in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) were studied. The improvement of living conditions, the evaluation of its significance and value in the treatment of AECOPD, and the addition of new ideas for the clinical treatment of AECOPD. Methods: this study is a randomized controlled clinical study. 80 patients with AECOPD were collected from 2015-2016-5 in Fenyang Hospital of Shanxi Province. Two groups (40 cases each) were randomly divided into two groups. The experimental group was treated with routine therapy of individual enteral nutrition after respiratory rehabilitation. The patients in the control group were treated with routine diet therapy. The patients in both groups were treated for 14 days. Before and after treatment, the patients were assessed with chronic obstructive pulmonary life scale (COPD) and the pulmonary function was measured. The results were statistically analyzed and concluded. Results the pulmonary function of the two groups was compared before treatment with FEV1 FVCV, serum prealbumin, serum albumin, CAT and lymphocyte. There was no significant difference in FEV1, serum prealbumin and serum albumin between the two groups after treatment. The difference was statistically significant. The effect of the experimental group was significantly higher than that of the control group. The difference was statistically significant (P 0.01). There was no significant difference between the experimental group and the control group (P < 0. 94, P 0. 94, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01). The difference was statistically significant (P 0.01), but there was no significant difference between the control group and the control group before and after treatment. Conclusion: compared with routine treatment, the combination of individualized enteral nutrition and respiratory rehabilitation can effectively improve lung function, immune function and nutritional status. Improve the quality of life of patients.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R563.9

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